Cell death by apoptosis is important in immune cell homeostasis and in the defense against infectious microorganisms. The physiological event of uptake and intracellular destruction of bacteria is a powerful apoptotic stimulus to macrophages and neutrophil granulocytes. In this study, we provide a molecular analysis of phagocytosis-induced apoptosis. Apoptosis was blocked by Bcl-2 in a mouse ma...

The BH3-only proteins of the Bcl-2 family initiate apoptosis through the activation of Bax-like relatives. Loss of individual BH3-only proteins can lead either to no phenotype, as in mice lacking Bik, or to marked cell excess, as in the hematopoietic compartment of animals lacking Bim. To investigate whether functional redundancy with Bim might obscure a significant role for Bik, we generated m...

Building Information Modeling (BIM) is emerging as a method of creating, sharing, exchanging and managing the building information throughout the lifecycle between all stakeholders. Radio Frequency Identification (RFID), on the other hand, has emerged as an automatic data collection and information storage technology, and has been used in different applications in the AEC/FM (Architecture, Engi...

A multitude of new applications is quickly emerging in the field of Building Information Models (BIM). BIM models describe buildings with respect to their spatial and especially semantic and thematic characteristics. Since BIM models are manually created during the planning and construction phase, they are only available for newly planned or recently constructed buildings. In order to apply the...

Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl+ leukemias. We found that imatinib kills Bcr/Abl+ leukemic cells by triggering the Bcl-2-regulated apoptotic pathway. Imatinib activated several proapoptotic BH3-only proteins: bim and bmf transcription was increased, and both Bim and Bad were activated posttranslationally. Studies using RNAi and cells from gen...

This paper presents our research and development of system interfaces between Building Information Modeling (BIM) and Building Energy Modeling (BEM), for supporting integrated architectural design and energy simulation. Our methods utilize the BIM authoring tools’ Application Programming Interface (API) to translate BIM into Object-Oriented Physical Models (in Modelica) for building thermal sim...

In view of the strategic plan of the Hong Kong Government to implement BIM in all public housing projects starting from 2014, there is a need to review the current use of BIM in Hong Kong. However, there is no thorough study conducted in Hong Kong to provide empirical data for further study. Although the study is conducted in Hong Kong, the results contribute practical insights to the subject i...

Building energy simulation has become an important method for reducing energy use and carbon dioxide emissions in sustainable building design. In the last decade, we have witnessed the employment of building information model (BIM) and internet technologies to be harnessed for energy-efficient building design. In this research the data exchange between a Building Information Model (BIM) and a B...

The introduction of direct detection devices in cryo-EM has shown that specimens present beam-induced motion (BIM). Consequently, in this work, we develop a BIM correction method at the image level, resulting in an integrated image in which the in-plane BIM blurring is compensated prior to particle picking. The methodology is based on a robust Optical Flow (OF) approach that can efficiently cor...