Triptycene is an aromatic compound with D3h symmetry, where three benzene rings are fused to a bicyclo[2.2.2]octatriene skeleton. 1,8,13-Substituted triptycenes exhibit interesting structural features: the C-1,8,13 substituents and bridgehead C-9 position located in same plane. Three faces of molecule open for interactions applications. This paper summarizes syntheses 1,8,13-substituted triptyc...

A convenient and efficient phosphine-catalyzed sequential annulation domino reaction between dienic sulfones and MBH carbonates has been developed. In the presence of 20 mol% of tris(4-fluorophenyl)phosphine, functionalized bicyclo[4.1.0]heptenes were prepared in excellent yields and stereoselectivities under mild conditions.

In the title mol-ecule, C(18)H(18)F(2)N(2)O(2)S, the two benzene rings, which are oriented in opposite directions with respect to the rigid 2,5-diaza-bicyclo-[2.2.1]heptane core, form a dihedral angle of 17.2 (1)°. Weak inter-molecular C-H⋯O, C-H⋯F and C-H⋯N contacts consolidate the crystal packing.

A high yielding metal-catalysed Conia-ene reaction of 2-acetylenic ketones for the synthesis of bicyclo[3.n.1]alkenes has been developed. This simple and efficient 6-endo-dig-cyclization protocol enables the synthesis of a wide variety of bicyclic systems, present in many natural products.

Two new dibenzocyclooctyne-thymidine monomers were incorporated into oligonucleotides and crosslinked to azide-labelled complementary strands across the DNA grooves. Equivalent reactions were successful using a (bicyclo[6.1.0]nonyne) alkyne. Oligonucleotides containing internal cyclooctyne and amino groups were simultaneously reacted with azides and NHS esters of different fluorescent dyes to p...

In the title compound, C(18)H(18)N(2)O, the cyclo-hexene and cyclo-hexane rings of the bicyclo-[2.2.2]oct-5-ene unit adopt distorted boat conformations. In the crystal, mol-ecules exist as C-H⋯N hydrogen-bonded centrosymmetric R(2) (2)(14) dimers, which are further linked by C-H⋯π inter-actions.