Immune recognition of tumor targets by specific cytotoxic lymphocytes is essential for the effective rejection of tumors. A phase I clinical trial of ipilimumab (an antibody that blocks CTLA-4 function) in combination with bevacizumab (an antibody that inhibits angiogenesis) in patients with metastatic melanoma found favorable clinical outcomes were associated with increased tumor endothelial a...

BACKGROUND Ovarian cancer is a leading cause of cancer-related mortality. Although the disease is relatively rare, it carries a disproportionately large morbidity burden. OBJECTIVE We conducted a cost-utility analysis from a Canadian public payer perspective to determine the cost effectiveness of bevacizumab, a newly available treatment option for recurrent ovarian cancer. METHODS Using a 7...

UNLABELLED Caffeine is thought to act as a central stimulant and to have effects on physical, cognitive, and psychomotor functioning. PURPOSE To examine the effects of ingesting a performance bar, containing caffeine, before and during cycling exercise on physical and cognitive performance. METHODS Twenty-four well-trained cyclists consumed the products [a performance bar containing 45 g of...

The authors compare the energy consumption and CO2 emissions from vehicles using internal combustion engines (ICE), battery electric (BEV), fuel cell (FCEV), two types of hybrid vehicles, BEV-ICE BEV-FCEV hybrid. This paper considers several scenarios for four countries’ electricity production primary sources to estimate total release. Energy vehicle per 100 km, during manufacturing, production...

Ball exit velocity (BEV) was measured from 17 experienced baseball hitters using wood and metal bats of similar length and mass but different moments of inertia. This research was conducted in response to safety issues for defensive players related to high BEV from metal baseball bats reported in the literature. Our purpose was to determine whether metal bats, with their lower swing moment of i...

OBJECTIVE To perform a systematic review and meta-analysis of randomized controlled trials that compared the efficacy of targeted therapy to conventional chemotherapy (CT) in patients with metastatic triple-negative breast cancer (TNBC). METHODS Several databases were searched, including Medline, Embase, LILACS, and CENTRAL. The primary end point was progression-free survival (PFS). We perfor...

Bird’s-Eye-View (BEV) maps have emerged as one of the most powerful representations for scene understanding due to their ability provide rich spatial context while being easy interpret and process. Such found use in many real-world tasks that extensively rely on accurate segmentation well object instance identification BEV space operation. However, existing algorithms only predict semantics spa...

The path choice behavior of battery electric vehicle (BEV) drivers is influenced by the lack of public charging stations, limited battery capacity, range anxiety and long battery charging time. This paper investigates the congestion/flow pattern captured by stochastic user equilibrium (SUE) traffic assignment problem in transportation networks with BEVs, where the BEV paths are restricted by th...

The main hindrance to a widespread market penetration of battery-powered electric vehicles (BEVs) has been their limited energy reservoir resulting in cruising ranges of few hundred kilometers unless one allows for recharging or switching of depleted batteries during a trip. Unfortunately, recharging typically takes several hours and battery switch stations providing fully recharged batteries a...