Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision repair (BER) mediated by DNA polymerase β (pol β) plays a crucial role in governing somatic TNR instability in a damage-location dependent manner. It has been shown that the activities and function of BER enzymes and cofactors can be modul...

8-alkylberberine homologues (Ber-C8-n, where n indicates carbon atom number of gaseous normal alkyl at 8 position, n = 0, 2, 4, 6, 8, 10, 12, or 16) were synthesized and their effects on the hemolysis of rabbit erythrocyte, the fluidity of membrane and the fluorescence of membrane protein were investigated by fluorescence analysis technique. Ber-C8-n with mediate length alkyl (4 < n < 10) exhib...

We examine adaptive modulation schemes for at-fading channels where the data rate, transmit power, and instantaneous BER are varied to maximize spectral e ciency, subject to an average power and BER constraint. Both continuous-rate and discrete-rate adaptation are considered, as well as average and instantaneous BER constraints. We nd that for a large class of modulation techniques and fading d...

This paper analyzes the interference of lightning flashes with multiple antennas wireless communication systems operating in the microwave band at 2.4 GHz and 5.2 GHz. A bit error rate (BER) measurement method was used to evaluate BER and packet error rate (PER) during 5 heavy thunderstorms on January 25 and March 17 to 20, 2011, respectively. In addition, BER measurements also were done on Jan...

This paper presents an improved version of multistage threshold decoding with a difference register (MTD-DR) for selforthogonal convolutional codes (SOCCs). An approximate lower bound on the bit error rate (BER) with the maximum likelihood (ML) decoding is also given. MTD-DR is shown to achieve an approximate lower bound of ML decoding performance at the higher Eb/N0. The code with larger minim...

Nuclear uracil-DNA glycosylase UNG2 has anestablished role in repair of U/A pairs resulting frommisincorporation of dUMP during replication. In anti-gen-stimulated B-lymphocytes UNG2 removes uracilfrom U/G mispairs as part of somatic hypermutationand class switch recombination processes. Usingantibodies specific for the N-terminal non-catalyticdomain of UNG2, we isol...

Frequency-domain equalization (FDE) based on the minimum mean square error (MMSE) criterion can provide a better bit error rate (BER) performance than rake combining. However, the residual inter-chip interference (ICI) is produced after MMSE-FDE and this degrades the BER performance. Recently, we showed that frequency-domain ICI cancellation can bring the BER performance close to the theoretica...

We obtain new inequalities involving Berezin norm and number of bounded linear operators defined on a reproducing kernel Hilbert space $${\mathscr {H}}.$$ Among many obtained here, it is shown that if A positive operator {H}}$$ , then $$\Vert A\Vert _{ber}={{{\textbf {ber}}}}(A)$$ where _{ber}$$ $${{{\textbf are the A, respectively. In contrast to numerical radius, this equality does not hold f...

The downlink (base-to-mobile) bit error rate (BER) performance for a mobile user with relatively weak received signal in a multicarrier-CDMA (MC-CDMA) cellular system can be improved by utilizing the site diversity reception. With joint use of MMSE-based frequency domain equalization (FDE) and antenna diversity combining, the site diversity operation will increase the downlink capacity. In this...

Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV. In order to identify DNA repair pathways required for HIV infection, we conducted a targeted siRNA screen using 232 siRNA pools for genes associated with DNA repair. Mapping the genes targeted by effective siRNA pools to well-defined DNA repair p...