New site-specific protein labeling (SSPL) reactions for targeting-specific, short peptides could be useful for the real-time detection of proteins inside of living cells. One SSPL approach matches bioorthogonal reagents with complementary peptides. Here, hydrazide reactive peptides were selected from phage-displayed libraries using reaction-based selections. Selection conditions included washes...

The prophage-inducing capability of hydroxylamine sulfate and 36 of its derivatives, and of hydrazine dihydrochloride and dihydrazine sulfate and 43 of their derivatives, was determined in Escherichia coli W1709 (X). Maximal nontoxic concentrations up to 1 mg/ml were tested. Hydroxylamine sulfate was active at 2.5 ,ug/ml and the following 17 derivatives were active at concentrations ranging up ...

HIV-1 integrase (IN) is an attractive and validated target for the development of novel therapeutics against AIDS. In the search for new IN inhibitors, we designed and synthesized three series of bis-amide and hydrazide-containing derivatives of malonic acid. We performed a docking study to investigate the potential interactions of the title compounds with essential amino acids on the IN active...

A synthesis of the tetrapeptide sequence As-Ag of glucagon is described that employs various blocking groups, coupling procedures, and routes. The threonyl-phenylalanyl-threonyl-seryl sequence A5-A8 in the hyperglycemic hormone, glucagon (Foa and Galansino, 1962), has been prepared by three different groups within the past four years (Beyerman and Bontekoe, 1964; Schroder and Gibian, 1962; Wuns...

diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (nsaids) suffer from the lethal gastro intestinal (gi) toxicities, diclofenac sodium is not an exception. the free –cooh group is thought to be responsible for the gi toxicity associated with all traditional nsaids. in the present research, the main motto...

New thiazolidine-4-one derivatives of ferulic acid have been synthesized in one step ("one-pot") by cyclization of ferulic acid hydrazide with different aromatic aldehydes and mercaptoacetic acid. The structure of the synthesized compounds was proved by infrared (IR) and nuclear magnetic resonance (H-NMR) spectroscopy. The in vitro antioxidant potential of the synthesized compounds was evaluate...

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

The title compound {systematic name: 4-methyl-N'-[(3E)-2-(1-methyl-prop-yl)-5-oxopyrrolidin-3-yl-idene]benzene-sulfono-hydrazide}, C(15)H(21)N(3)O(3)S, is the condensation product of deacetyl tenuazonic acid (DTA) and p-toluene-sulfonohydrazide. The crystal structure consists of chains along [100] linked by N-H⋯O hydrogen bonds.

A series of novel pyridine carbohydrazide derivatives were synthesized from the reaction of 2-chloro-6-hydrazino-isonicotinic acid hydrazide with selected active reagents. All prepared compounds were tested as analgesic and anticonvulsant agents. The pharmacological screening showed that many of these compounds have good activities comparable to those of valdecoxib and carbamazepine as referenc...

A Novel compound namely N-(Nicotinoyl) 3,5 dimethyl-4-(N-4-sulfamoylazo)-1,2-diazole has been synthesised by two step processes. Synthesis of N-4-sulphamoylphenylhydrazono-3,5-dimethyl propane1,3-dione and sulphonamide, which interacting with Nicotinic acid hydrazide to form final compound. The newely synthesised compound N-(nicotinoyl)-3,5-dimethyl 4-(N-4-sulfamoyl phenyl azo) 1,2-diazoles was...