Objective: Synthesis and in vitro antimicrobial screening of 2,6-diaminopyridine Schiff bases isatin derivatives.
 Methods: Isatin it’s 5-substituted derivatives (S1-5) were prepared by Sandmeyer method N2-Benzylidenepyridine-2,6-Diamine (M) was obtained the reacting with benzaldehyde. (MS1-5) (M). Resultant compound structures confirmed some analytical techniques’ data. All synthesized sc...

Artificial enzymes utilizing the genetically encoded non-proteinogenic amino acid p-aminophenylalanine (pAF) as a catalytic residue are able to react with carbonyl compounds through an iminium ion mechanism promote reactions that have no equivalent in nature. Herein, we report vivo biocatalytic cascade is augmented such artificial enzyme-catalysed new-to-nature reaction. The enzyme this study p...

A novel catalytic synthesis of 3,3'-(arylmethylene)-bis-(4-hydroxy-2H-chromene-2-one) derivatives from a tandem condensation reaction of 4-hydroxycoumarin and aromatic aldehydes has been developed. The reaction occurs in water in the presence of Melamine trisulfonic acid as catalyst to give the corresponding products in good to high yields. This green approach has several advantages such as sho...

Schiff bases of Benzene sulfonyl hydrazide (SBSZ) (1a-e) were prepared by using various benzaldehyde derivatives. SBSZ then condensed with mercapto acetic acid. The obtained resultant 2-thiazolidinone derivatives (2a-e) 5-nitro-2furfuralidine i.e. (Z)-N-(5-((5-nitrofuran-2-yl) methylene)-4-oxo-2-substitutedthiazolidin-3-yl) benzenesulfonamide (3a-e). These further phenyl urea to yield fused het...

The title compound, C(8)H(9)N(3)S, contains two mol-ecules in the asymmetric unit. One mol-ecule is close to being planar (r.m.s. deviation from the mean plane = 0.06 Å for the non-H atoms), while the other exhibits a dihedral angle of 21.7 (1)° between the benzene ring and the mean plane of the thio-semicarbazone unit. Inter-molecular N-H⋯S hydrogen bonds link the mol-ecules into layers parall...

meldrum's acid, 2'5-diphenyl-1'3-dioxane-4'6-dione, was produced by [2+2] cycloadditions of the (chlorocarbony1)phenylketene with benzaldehyde. acid hydrolysis of the meldrum's acid regenerated benzaldehyde and also yielded phenylacetic acid as the final product