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The size of this monograph and its moderate price belie the wealth of information contained within its pages. This book is a competent attempt to assemble biochemical and physiological data and correlate these findings with ultrastructure of the rat anterior pituitary. There are twelve chapters. The first two are devoted to definitions and experimental procedures. The next six chapters center a...
The marriage of linguistic theory and language acquisition is approaching its golden anniversary. In her 1966 dissertation Ursula Bellugi provided a transformational analysis of the development of negation in English-speaking children. On the model of the Standard Theory of Generative Grammar (Chomsky 1965), she proposed a system of phrase structure and transformational rules to describe the va...
We explore the microbiota of 18 body sites in over 200 individuals using sequences amplified V1-V3 and the V3-V5 small subunit ribosomal RNA (16S) hypervariable regions as part of the NIH Common Fund Human Microbiome Project. The body sites with the greatest number of core OTUs, defined as OTUs shared amongst 95% or more of the individuals, were the oral sites (saliva, tongue, cheek, gums, and ...
Macroeconomic forecasts are frequently produced, widely published, intensively discussed and comprehensively used. The formal evaluation of such forecasts has a long research history. Recently, a new angle to the evaluation of forecasts has been addressed, and in this review we analyse some recent developments from that perspective. The literature on forecast evaluation predominantly assumes th...
Introduction The nonapeptides oxytocin and vasopressin belong to an ancient peptide hormone family with representatives in both protastome and deuterostome lineages. The two mammalian hormones themselves probably diverged from a common ancestor at about the time that vertebrates evolved on the earth. There are discrete oxytocin-like and vasopressin-like peptides in teleost fish; only in cyclost...
BACKGROUND Recent successes in the treatment of in-stent restenosis (ISR) by drug-eluting stents belie the challenges still faced in certain lesions and patient groups. We analyzed human coronary atheroma in de novo and restenotic disease to identify targets of therapy that might avoid these limitations. METHODS AND RESULTS We recruited 89 patients who underwent coronary atherectomy for de no...
Quantitative estimates of the range loss of mountain plants under climate change have so far mostly relied on static geographical projections of species’ habitat shifts1–3. Here, we use a hybrid model4 that combines such projections with simulations of demography and seed dispersal to forecast the climate-driven spatio-temporal dynamics of 150 highmountain plant species across the European Alps...
In a famous 1958 article, Yale Kamisar brilliantly examined the hazards of abuse and of slippery slope extensions that subsequently, for 46 years, served to thwart legalization of physician-assisted death (PAD). This paper shows that during the same period law and culture have effectively accepted a variety of ways for stricken people to hasten death, with physicians involved in diverse roles. ...
Invertebrates have proved to be important experimental systems for examining questions related to growth cone navigation and nerve formation, in large part because of their simpler nervous systems. However, such apparent simplicity can be deceiving because the final stereotyped patterns may be the result of multiple developmental mechanisms and not necessarily the sole consequence of the pathwa...
The Italian authorities claim that more than 17 people have died this summer collecting mushrooms from its northern and central mountains. People, it appears, are taking increasing risks in gathering these most prized elements of Italian food. And, of course, mushrooms feature as prized items in the recipes of many other cuisines. But the prominence and respect for the few species of edible fun...
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