Fahr's disease or idiopathic basal ganglia calcification is a rare pathology. The most common clinical manifestations are movement disorders, psychiatric cerebellar syndrome, seizures and cognitive disorders. We report the case of 47-year-old female patient with revealed by brutal right hemiplegia.

The article presents a clinical case of rare autoinflammatory disease – family Muckle Wells syndrome. diversity manifestations and the impossibility confirming diagnosis without genetic study by DNA sequencing determine complexity delay in diagnosis. development severe complications and, as consequence, fatal outcome necessitates early described demonstrates importance for timely disease, featu...

Characteristic feature of PFAPA syndrome is periodic episodes of fever recurring in 21-28 days in infants and young children. Fever is accompanied by aphtosus stomatitis, pharyngitis and cervical adenopathy. Diagnosis of this syndrome are based on typical clinical manifestations, because there are no characteristic changes in laboratory findings. The reason of this syndrome is unknown. We descr...

OBJECTIVE: To review the literature on the hypoxic-ischemic syndrome, emphasizing its physiopathology, clinical manifestations, and treatment. SOURCES: Electronic search in the Medline and LILACS databases, with selection of the most relevant articles. SUMMARY OF THE FINDINGS: The hypoxic-ischemic syndrome is a multisystem disease with generalized manifestations. The physiopathology is based on...

The antiphospholipid syndrome (APS) defines the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability or thrombophilia (the term of "sticky blood" is sometimes used in APS). Antiphospholipid antibodies comprise a broad family of antibodies including both lupus anticoagulants and anticardiolipin antibodies. The pathogenesis of APS remains unclear. Neverthe...