background: glucantime ® is the first- line drug for the treatment of all forms of leishmaniasis. unfortunately, the prevalence of parasites becoming resistant to glucantime ® is increasing in several parts of the world including iran. as protein is the most important target for drugs in response to a variety of signals including drugs so, it seems expression protein patterns in sensitive and r...

objective: various approaches have been offered for resolution of pain resulting from spinal cord injuries. one approach is the use of herbal and natural products. in the present research, as a preliminary study, we investigate the effect of crocin on chronic pain induced by contusion in the rat spinal cord (sci). methods: we randomly divided female wistar rats into five groups. groups i and ii...

Activation of the mesolimbic dopamine reward pathway by acute ethanol produces reinforcement and changes in gene expression that appear to be crucial to the molecular basis for adaptive behaviors and addiction. The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize pat...

the purpose of this work is to promote and facilitate forensic profiling and chemical analysis of illicit drug samples in order to determine their origin, methods of production and transfer through the country. the article is based on the gas chromatography analysis of heroin samples seized from three different locations in serbia. chemometric approach with appropriate statistical tools (multip...

<p style="text-align: justify;"><strong>Objective. </strong>Systematization and generalization of research data on the impact early institutionalization biological indicators children's development, a description underlying physiological mechanisms relations between their behavioral manifestations in children.</p> justify;"><strong>Background. </stro...

The sensation of hunger after a period of fasting and of satiety after eating is crucial to behavioral regulation of food intake, but the biological mechanisms regulating these sensations are incompletely understood. We studied the behavioral and physiological adaptations to fasting in the vinegar fly (Drosophila melanogaster). Here we show that both male and female flies increased their rate o...

Behavioral testing is a critical step in assessing the validity of rodent models of neurodegenerative disease, as well as evaluating the efficacy of pharmacological interventions. In models of Huntington's disease (HD), a gradual progression of impairments is observed across ages, increasing the need for sensitive, high-throughput and longitudinal assessments. Recently, a number of automated sy...

We tested the application of qualitative behavioral assessment (QBA) as a welfare assessment tool. Sheep were exposed to road transport treatments, and behavioral expressions were compared between experimental treatments and validated by correlation with physiological measures. We compared journeys differing in ventilation (closed vs. open-sided trailer), flooring (grip vs. nongrip flooring), a...

Online behavioral advertising (OBA) refers to the practice of tracking users across web sites in order to infer user interests and preferences. These interests and preferences are then used for selecting ads to present to the user. There is great concern that behavioral advertising in its present form infringes on user privacy. The resulting public debate — which includes consumer advocacy orga...