Glyoxalase 1 (GLO1) is a ubiquitous cellular enzyme that participates in the detoxification of methylglyoxal (MG), a cytotoxic byproduct of glycolysis that induces protein modification (advanced glycation end-products, AGEs), oxidative stress, and apoptosis. The concentration of MG is elevated under high-glucose conditions, such as diabetes. As such, GLO1 and MG have been implicated in the path...

Services Oriented Architectures preach loosely-coupled services and high–level composition mechanisms, using for example Web Services to define services and Orchestrations to compose them. But orchestration evolutions imply modification at source code level. This article shows how the orchestration paradigm itself can be used to support evolution of Web Services Orchestrations through a behavio...

1. Explain the causes of exercise intolerance. 2. List the two most useful diagnostic tools for assessing exercise intolerance. 3. Describe how pulmonary dysfunctions, cardiac diseases, and muscular disorders affect exercise tolerance. 4. Delineate the nonpharmacologic treatment of choice for most cases of exercise intolerance. 5. Explain the role of behavioral modification within a family-base...

Sexual behavior problems in the stallion include several distinct types of dysfunction. Successful treatment, whether by tradit ional behavior modification or by pharmacological manipulation, usually depends on diagnosis of the specific dysfunctions involved. The following d’ lscussion of behavioral problems, evaluation, and therapy is organized according to the common types of sexual behavior ...

Like other reinforcing stimuli, drug effects may vary with the reinforcement history of an individual. Data are presented which demonstrate that histories contribute to individual differences in response to reinforcement contingencies and modification of maladaptive behavioral persistence. Possible relevance of these findings to an understanding of drug effects in humans is discussed.

Stress urinary incontinence is a prevalent condition in women with a significant negative effect on quality of life. Intervention includes behavioral modification, intravaginal devices, pelvic floor muscle exercises, biofeedback, functional electrical stimulation, and surgical procedures. We will review a new in-office procedure for the treatment of SUI that may serve as a viable nonsurgical op...

After reading this article on overac­ tive bladder, the family physician will be able to: 1. Characterize the impact of overactive bladder in women 2. Describe the role of patient education, behavioral modification, and pharma­ cologic treatment 3. Select antimuscarinic therapy based on patient characteristics and comorbidities 4. Describe the efficacy and safety of mira­ begron and onabotulinu...

Censor et al. (2014) combine behavioral, TMS, and neuroimaging to identify task-free neural signatures that relate to modification of motor memories. Modulation of memories using TMS may provide a powerful approach to improve human brain function in neurorehabilitation and cognitive neuroscience.