نتایج جستجو برای: behavioral abnormalities
تعداد نتایج: 247477 فیلتر نتایج به سال:
Several presynaptic proteins involved in neurotransmitter release in the CNS have been implicated in schizophrenia in human clinical genetic studies, in postmortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1alpha mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1alpha exhibit abnormalities i...
Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findin...
Depression is a common neuropsychiatric disorder that causes profound disability worldwide, yet the underlying mechanism remains unclear. Thus, present study aimed to evaluate effects of two-hit model depression on glial activation, parvalbumin (PV) interneuron, oscillation activity, and behavior alternations, whether chronic fluoxetine treatment can reverse these abnormalities. Male mice were ...
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