Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/...

From December 2002 to February 2003, 15 isolates of pandrug-resistant unidentified Acinetobacter species were recovered from seven patients treated on different wards or intensive care units. Both 16S-23S rRNA intergenic spacer PCR-restriction fragment length polymorphism profiles and sequence analysis of these isolates identified them as Acinetobacter baumannii. This pandrug-resistant A. bauma...

The gram negative rod Acinetobacter baumannii is a soil and water saprophyte characterized by a high degree of innate and acquired antibiotic resistance. While it can colonize healthy hosts, it is also a well-established hospital-acquired pathogen, especially in intensive care and surgical units. The pathogen does not have many of the traditional virulence factors for producing disease in healt...

Acinetobacter baumannii is a multidrug-resistant pathogen associated with severe infections in hospitalized patients, including pneumonia, urinary and bloodstream infections. Rapid detection of A. baumannii infection is crucial for timely treatment of septicemic patients. The aim of the present study was to develop a specific marker for a quantitative polymerase chain reaction (PCR) assay for t...

Acinetobacter baumannii has emerged as one of the WHO most dangerous pathogens hit-list and considered a priority of the Public Health Services worldwide. It can cause a wide range of opportunistic infections, typically involving ventilatorassociated pneumonia, septicaemia and surgical wound infections mainly in immunocompromised patients [1]. The general morbidity and mortality rates of infect...

A total of 152 clinical isolates of Acinetobacter baumannii from 152 patients were identified by carbon source utilization tests and examined serologically. Polyclonal rabbit immune sera against A. baumannii strains were used in checkerboard tube agglutination tests, and 20 serovars were identified. One (serovar 19) cross-reacted with genospecies 3 (serovar 3), a closely related member of the g...

Among Acinetobacter species, A. baumannii and other closely related species are commonly implicated in nosocomial infections. These organisms are usually multidrug resistant (MDR), and therapeutic options to treat A. baumannii infections are very limited. Clinicians have been resorting to older antimicrobial agents to treat infections caused by MDR A. baumannii, and some of these agents have do...

BACKGROUND Antimicrobial resistance is one of the most challenging issues in modern medicine. METHODS We evaluated the secular trends of the relative frequency of blood isolates and of the pattern of their in vitro antimicrobial susceptibility in our hospital during the last four and a half years. RESULTS Overall, the data regarding the relative frequency of blood isolates in our newly foun...