The aim of the present study was to formulate and evaluate Posaconazole loaded NLCs gel using solid lipid as GMS, liquid oleic acid surfactants tween 80 span 80, with help high-speed homogenization followed by sonication technique improve bioavailability, avoid oral side effects, achieve site-specific delivery patient compliance. prepared different drug: carrier ratios high speed technique. % e...

Substrate-mediated gene delivery is a promising method due to its unique ability to preconcentrate exogenous genes onto designated substrates. However, many challenges remain to enable continuous and multiround delivery of the gene using the same substrates without depositing payloads and immobilizing cells in each round of delivery. Herein we introduce a gene delivery system, nanosubstrate-med...

BACKGROUND Virus-like particles (VLP) have an increasing range of applications including vaccination, drug delivery, diagnostics, gene therapy and nanotechnology. These developments require large quantities of particles that need to be obtained in efficient and economic processes. Production of VLP in yeast is attractive, as it is a low-cost protein producer able to assemble viral structural pr...

BACKGROUND Poly(4-hydroxybutyrate) (P4HB), belonging to the family of bacterial polyhydroxyalkanoates (PHAs), is a strong, flexible and absorbable material which has a large variety of medical applications like tissue engineering and drug delivery. For efficient production of P4HB recombinant Escherichia coli has been employed. It was previously found that the P4HB synthesis is co-related with ...

TNFα is one of the initial and important mediators to activate downstream signaling pathways by binding to trimerized TNFα receptors (TNFR), and thus is an ideal drug target for cancer therapy. Taking advantage of intrinsic homotimerization of the globular domain of adiponectin (gAD), we have developed a novel TNFα antagonist, the trimerized fusion protein named sTNFRII-gAD. However, our previo...

The detection and exact quantification of the presence of GMOs (genetically modified organisms, also named as living modified organisms, LMOs) grains has become very important in international commercial transactions, especially from countries producing both types of commodities, GMOs and GMO-free. This makes necessary to check every batch previous delivery to the recipient country. Several PCR...

This article describes the dynamic model of assembly process of reducer is presented as part of an activity performed in a workshop kanban simulation aimed at students of industrial engineering. The main objective of the model developed is to analyze the behavior of inventory levels workstations and accumulations of kanban cards (production orders) derived from the effects of the cycle time kan...

The present study deals with the batch and fed-batch mass production of Steinernema carpocapsae. S. carpocapsae is an entomoparasitic nematode that is used as a biological control agent of soil-borne crop insect pests. The ability and efficiency of fed-batch culture process was successful through the utilization of the nematode’s bacterial symbiont Xenorhabdus nematophila. Results from the fed-...

An integrated strategy for the tracking control of product qualities in batch processes is proposed by combing batch-to-batch iterative learning control (ILC) with on-line shrinking horizon model predictive control (SHMPC) within a batch. ILC is used in batch-to-batch control and the convergence of batch-wise tracking error under ILC is guaranteed. On-line SHMPC within a batch can reduce the ef...