BACKGROUND The diagnostic power of the transferrin receptor-ferritin (TfR-F) index for identification of iron responsiveness in long-term hemodialysis (HD) patients compared with the routine markers recommended by the current US and European guidelines was appraised. METHODS Initially, 121 long-term HD patients with a serum ferritin level less than 800 microg/L and on recombinant erythropoiet...

Introduction Treatment-free remission (TFR) in patients with chronic myeloid leukemia phase is considered a safe option if suitable molecular monitoring available. However, the question arises as to which factors can contribute maintenance of TFR, and immunologic surveillance remaining leukemic cells believed be one them. Argentina Stop Trial an open-label, single-arm, multicenter trial assessi...

Myrskylä et al. (2009) found that the relationship between the human development index (HDI) and the total fertility rate (TFR) reverses from negative (i.e., increases in HDI are associated with decreases in TFR) to positive (i.e., increases in HDI are associated with increases in TFR) at an HDI level of 0.86. In this article, we show that the reversal in the HDI-TFR relationship is robust to n...

Synthesis of proteins for iron homeostasis is regulated by specific, combinatorial mRNA/protein interactions between RNA stem-loop structures (iron-responsive elements, IREs) and iron-regulatory proteins (IRP1 and IRP2), controlling either mRNA translation or stability. The transferrin receptor 3'-untranslated region (TfR-3'-UTR) mRNA is unique in having five IREs, linked by AU-rich elements. A...

The production of antibody is precisely controlled during the germinal center (GC) reaction. This process is dependent on the help from follicular T helper (Tfh) cells to germinal center (GC) B cells and is regulated by regulatory follicular T helper (Tfr) cells. How Tfr cells develop and how their suppressive activity functions are not well understood. Here, we found that Stat3 is indispensibl...

A subset of sickle cells have an increased density at the reticulocyte stage of development, indicating that they are either abnormally dense upon release from the bone marrow or become dense quickly in the circulation. These cells are of interest because they most likely have severely disrupted cation regulation and a short lifespan. Based on the distribution of fetal hemoglobin (HbF) in the d...

We challenge the perception that we live in a “proper world,” where complex random signals can always be assumed to be proper (also called circularly symmetric). Rather, we stress the fact that the analytic signal constructed from a nonstationary real signal is in general improper, which means that its complementary correlation function is nonzero. We explore the consequences of this finding in...

The study of the electroencephalographic (EEG) signal contributes to sleep analysis. In the microstructure of the sleep EEG signal, transient patterns are characterized by their frequency content and their time duration. The Time– Frequency Representations (TFR) take into account these time – frequency characteristics but the lower energy transient signals are masked by higher energy ones. In o...

The common track fusion algorithms in multi-sensor systems have some defects, such as serious imbalances between accuracy and computational cost, the same treatment of all the sensor information regardless of their quality, high fusion errors at inflection points. To address these defects, a track fusion algorithm based on the reliability (TFR) is presented in multi-sensor and multi-target envi...

Transferrin receptor (TfR) has been explored as a target for antibody-based therapy of cancer. In the previous study, we reported a murine anti-TfR monoclonal antibody (mAb) 7579 had good anti-tumor activities in vitro. In an attempt to reduce its immunogenicity and enhance its ability to recruit immune effector mechanism in vivo, we herein developed its chimera in the baculovirus/insect cell e...