introduction: despite advances in cardiac surgery, many patients might still encounter some post-surgical complications and difficulties. to overcome such difficulties, they should receive the required education. in view of the fact that determining the educational needs is the first step in educational planning, the present study aims to determine the educational needs of patients undergoing h...

background : postmenopausal hot flash is a common disease amongst women with high prevalence of 75%. hormone replacement therapy (hrt) is a well-known relief of symptoms which has disadvantages such as side effects and contraindication for certain types of hormone related diseases and breast or estrogen related cancers. one of the alternatives is acupuncture which is an east asian and more spec...

this study tries to codify a proper mathematical model which can be predict the costs of repair and maintaining the tractors as precisely as possible for three common models of tractors in shahid beheshti cultivation firm in andimeshk-ahvaz road of dezfoul. studied tractors include: newhland tm155 tractor which is chosen from the most perfect file of 10 tractor machines and jandier tractor-3140...

The National Institute for Health and Clinical Excellence (NICE) has thus far relied on historical data and predominantly industry-sponsored trials to provide evidence for venous thromboembolic (VTE) prophylaxis in joint replacement patients. We argue that the NICE guidelines may be reliant on assumptions that are in need of revision. Following the publication of large scale, independent observ...

OBJECTIVE Explore professional relationships between Chief Nurse Executives (CNEs) and Chief Executive Officers (CEOs); CNE ethnic diversity; and CNE replacement costs. BACKGROUND Theoretical frameworks - Marilyn Ray's Theory of Bureaucratic Caring, and Turkel's Theory of Relational Complexity espousing economic as well as caring variables. METHODS Exploratory mixed-method descriptive desig...

OBJECTIVE To determine the extent to which prostheses with no readily available evidence to support their use are being implanted in primary total hip arthroplasty. DESIGN Systematic review of the literature. DATA SOURCES The 9th annual report of the National Joint Registry of England and Wales (NJR) was analysed to identify prostheses with an Orthopaedic Data Evaluation Panel rating of "un...

We previously used changes in the near-UV circular dichroism and fluorescence spectra of DNA base analogue probes placed site specifically to show that the first three base pairs at the fork junction in model replication fork constructs are significantly opened by "breathing" fluctuations under physiological conditions. Here, we use these probes to provide mechanistic snapshots of the initial i...

Val(121) is positioned immediately above the extrahelical cytosine in HhaI DNA C(5)-cytosine methyltransferase, and replacement with alanine dramatically interferes with base flipping and catalysis. DNA binding and k(cat) are decreased 10(5)-fold for the Val(121) --> Ala mutant that has a normal circular dichroism spectrum and AdoMet affinity. The magnitude of this loss of function is comparabl...

Two similar, but not identical, models have been proposed for the amino acid-base pair contacts in the CAP-DNA complex ('Model I,' Weber, I. and Steitz, T., Proc. Natl. Acad. Sci. USA, 81, 3973-3977, 1984; 'Model II,' Ebright, et al., Proc. Natl. Acad. Sci. USA, 81, 7274-7278, 1984). One difference between the two models involves Glu181 of CAP. Model I predicts that Glu181 of CAP makes two spec...