The screening of large numbers of compounds or siRNAs is a mainstay of both academic and pharmaceutical research. Most screens test those interventions against a single biochemical or cellular output whereas recording multiple complementary outputs may be more biologically relevant. High throughput, multi-channel fluorescence microscopy permits multiple outputs to be quantified in specific cell...

Objective: A randomized, controlled trial was performed to evaluate a computer-assisted method for counting sponges using a barcode system. Background: Retained sponges are a rare and preventable problem but persist in surgery despite standardized protocols for counting. Technology that improves detection of counting errors could reduce risk to surgical patients. Methods: We performed a randomi...

Self-localization as precondition for goal-oriented behavior is a fundamental property an autonomous mobile robot needs to be equipped with. This paper addresses the self-localization problem from a pragmatical point of view since it argues for using passive artificial landmarks in order to support mobile robot localization in indoor environments. The idea is to further improve already existing...

Against the odds of membrane resistance, members of the BIN/Amphiphysin/Rvs (BAR) domain superfamily shape membranes and their activity is indispensable for a plethora of life functions. While crystal structures of different BAR dimers advanced our understanding of membrane shaping by scaffolding and hydrophobic insertion mechanisms considerably, especially life-imaging techniques and loss-of-f...

The Canadian Pharmaceutical Bar Coding Project was a multi-year, multi-stakeholder national initiative designed to establish a pan-Canadian approach to automated identification of medications along the entire supply chain and medication-use system, from pharmaceutical manufacturers to the patient’s bedside. The project was co-led by the Institute for Safe Medication Practices Canada (ISMP Canad...

Arash T. Dabestani, Pharm.D., M.H.A., and Alicia B. Perry, Pharm.D., are gratefully acknowledged for drafting versions of this statement. The ASHP Section of Pharmacy Informatics and Technology Advisory Group on Automation and Documentation is also gratefully acknowledged for reviewing drafts and providing advice on the development of this statement. ASHP also gratefully acknowledges the follow...