Since the first successful aggregation of mouse embryos was reported by TARKowsKi,ii) many studies on chimera production have been carried out.S'6'7) Chimeras produced by the aggregation of early embryos have been widely used in experimental investigations of mammalian embryolegy and developmental genetics.4'9) Chimeric experimental animals have also been used to study some problems of human ge...

Background: Diabetes is a metabolic disorder that in long period can damage the testis and reduce the semen quality. Therefore, it can impair the male fertility potential. Recently, different herbal therapeutic treatment for protection of diabetes and its pathologic effects have been used. The aim of current study is to evaluate the protective effect of Equisetum arvense extract (EE) on in vitr...

The developmental competence of in vitro cultured embryos vitrified-warmed at an early cleavage stage (2- or 4, 8-cell stage) was examined by both direct transfer into recipient animals and after in vitro manipulation for chimeric mice production using embryonic stem (ES) cells. Vitrified-warmed embryos transferred at the morulae and blastocyst stages showed fetus development comparable to cont...

Introduction: Chlorpyrifos (CPF), an organophosphate insecticide, was evaluated for potential teratogenic effects in mice. A single oral dose of insecticide (i.e. 72, 36 18 or 9 mg/kg) was given to the pregnant females on gestation day6 (GD6). These doses correspond 50, 25, 12.5 and 6.25% to the calculated LD50 value (144 mg/kg) for the pregnant mice. No signs of overt toxicity were observed at...

the aim of this sutdy is to prepare histocompatability y(hy) antibody in female mouse at the first phase (current study), and to separate mouse embryos with regard to their sex, to be able to obtain offsprings of disired sex, by means of hy antibody, at the second phase. totally 421 balb/c inbred mice were used. antibodies were produced in females by intraperitonial injections of spleen and tes...

Introduction: Maytenus macrocarpa (MM) "Chuchuhuasi" is a native plant from the Amazon region of South America, widely used in traditional medicine due its anti-inflammatory, analgesic and anti-tumor properties. However, effects on reproductive physiology male fertility have not been elucidated. Methods: Preclinical experimental study cases controls. Male mice with eight weeks birth were admini...

Current study includes an investigation of the effects Dexamethasone (Dex) drug on neural tube development. A total 60 pregnant mice were allocated into four groups at random, with 15 each group, While control group received injections a Normal Saline 0.9 %, group's members given specified dose and different times. All animals their doses through tail intravenous injection specific periods preg...

(i) Objective: This study was conducted to analyze the effect of lead acetate on the serum estrogen and progesterone levels in adult mice and the role of garlic extract. (ii) Study Design: Laboratory based Randomized Control Trial. (iii) Place and duration of study: Anatomy Department, Army Medical College, Rawalpindi in collaboration with National Institute of health from April-June 2013. (iv)...