Nuclear medicine imaging techniques offer whole body imaging for localization of number and site of infective foci inspite of limitation of spatial resolution. The innate human immune system contains a large member of important elements including antimicrobial peptides to combat any form of infection. However, development of antibiotics against bacteria progressed rapidly and gained popularity ...

Fungal resistance to traditional drugs calls for new antimicrobial agents. In mammals, defensins and cathelicidins are two major families of antimicrobial peptides. Cathelicidins are cationic peptides with a conserved N-terminal cathelin-like domain and a variable C-terminal antimicrobial domain. Cathelicidins rapidly kill Candida and other yeast spp.1 Candida infection with C albicans is the f...

background: the rise of opportunistic fungal infections highlights the need for development of new antimicrobial agents. antimicrobial peptides (amps) and antifungal peptides (afps) are among the agents with minimal resistance being developed against them, therefore they can be used as structural templates for design of new antimicrobial agents. methods: in the present study four antifungal pep...

Solid-state NMR spectroscopy is used to determine the membrane-bound topological structure of a cationic beta-hairpin antimicrobial peptide in which the number of Arg residues has been halved. The parent peptide, PG-1, was previously found to form transmembrane beta-barrels in anionic membranes where the Arg residues complex with the lipid phosphate groups to cause toroidal pore defects in the ...

The objectives of this research were to validate the sensitivity and precision of an in vitro assay for evaluating the efficacy of antimicrobials, to evaluate the ability of natural animal proteins/peptides to kill in vitro antibiotic-resistant, as well as, -susceptible bacteria, and to determine the effects of key components of animal digesta (e.g., pH, mineral content, and proteolytic digesti...