We used wild-type (WT) mice and mice engineered to express either apoB-100 only (B100 mice) or apoB-48 only (B48 mice) to examine the effects of streptozotocin-induced diabetes (DM) on apoB-100- and apoB-48-containing lipoproteins. Plasma lipids increased with DM in WT mice, and fat tolerance was markedly impaired. Lipoprotein profiles showed increased levels and cholesterol enrichment of VLDL ...

Study objectives: Vitamin D blood levels of 60–80 ng/ml promote normal sleep. The present study was undertaken to explore why this beneficial effect waned after 2 years as arthritic pain increased. Pantothenic acid becomes coenzyme A, a cofactor necessary for cortisol and acetylcholine production. 1950s experiments suggested a connection between pantothenic acid deficiency, autoimmune arthritis...

The aim of the present study was to assess the genotoxicity reduction in post vermicompost feed mixtures of bagasse (B) waste using earthworm Eisenia fetida. The genotoxicity of bagasse waste was determined by using Allium cepa root chromosomal aberration assay. Bagasse was amended with cattle dung in different proportions [0:100 (B0) 25:75 (B25), 50:50 (B50), 75:25 (B75) and 100:0 (B100)] on d...

We previously characterized a mutant apoB allele (the apoB86 allele) that produces both a truncated apoB (apoB86) and a full-length apoB100. The mutant allele contained a deletion of a single cytosine in exon 26, creating a stretch of eight consecutive adenines in the -1 reading frame. The altered reading-frame allele was restored, with approximately 10% efficiency, by the transcriptional inser...

Metakaolins (MKs) prepared from low-grade kaolins located in the Alvarães (A) and Barqueiros (B) regions of Portugal were used as aluminosilicate source to compare their effect on compressive strength heavy metal adsorption geopolymers. Natural zeolite, an inexpensive, efficient adsorbent, was additive formulations enhance geopolymers’ capacities reduce MK utilization’s environmental footprint....

With their higher sustainability index, biofuels, environmentally-friendly and renewable nature is a viable alternative energy source in the transportation sector. This study presents effect of waste cooking oil (WCO) biodiesel on performance, combustion, emission from compression ignition engine. The was blended with diesel varying proportions 5% 95% (designated as B5), 10% (B10), 15% (B15), 2...

Biodiesel is widely accepted as a fuel that similar to diesel with various advantages. Biodiesel's low-temperature flow qualities are one of its characteristics limits use. The goal this study was see how volumetric blends palm biodiesel and diesel, affected the performance emissions fired vertical coil type, water tube, non IBR boiler. Various were prepared like PB25, PB50, PB75, PB100 test in...

Although apolipoprotein B100 (ApoB100) plays a key role in peripheral fat deposition, it is not considered a suitable therapeutic target in obesity. In the present study we describe a novel ApoB100 mimotope, peptide pB1, and the use of pB1-based vaccine-like formulations (BVFs) against high-fat diet (HFD)-induced obesity. In HFD- compared with chow-fed adolescent mice, BVFs reduced the 3-month ...

Mipomersen is a 20mer antisense oligonucleotide (ASO) that inhibits apolipoprotein B (apoB) synthesis; its low-density lipoprotein (LDL)-lowering effects should therefore result from reduced secretion of very-low-density lipoprotein (VLDL). We enrolled 17 healthy volunteers who received placebo injections weekly for 3 weeks followed by mipomersen weekly for 7 to 9 weeks. Stable isotopes were us...

Spray characteristics have an important role in improving the quality of combustion compression engines. This study analyzes effect ambient temperature on spray including tip penetration, angle and velocity spray. The research method uses experimental with variations 60 o C, 80 100 C controlled using a thermocouple pressure 0.3 MPa. composition fuel diesel (diesel 100%), B30 (30% biodiesel), B1...