نتایج جستجو برای: b acute lymphoblastic leukemia

تعداد نتایج: 1388968  

Journal: :Haematologica 2014
Giovanni F Torelli Nadia Peragine Sara Raponi Daria Pagliara Maria S De Propris Antonella Vitale Alice Bertaina Walter Barberi Lorenzo Moretta Giuseppe Basso Angela Santoni Anna Guarini Franco Locatelli Robin Foà

In this study, we aimed to investigate the pathways of recognition of acute lymphoblastic leukemia blasts by natural killer cells and to verify whether differences in natural killer cell activating receptor ligand expression among groups defined by age of patients, or presence of cytogenetic/molecular aberrations correlate with the susceptibility to recognition and killing. We analyzed 103 newl...

بوستانی, حسن, رستمی, اسماعیل, صادقیان, محمد هادی, قوطاسلو, عباس, کیانی قلعه سردی, امید,

Background and Objective: Acute lymphoblastic leukemia is a disorder caused by the proliferation of malignant immature lymphoid cells. GRAF (GTPase regulator associated with focal adhesion kinase) which acts as a tumor suppressor gene is disabled in hematologic malignancies due to genetic and epigenetic abnormalities. In this study, GRAF gene expression was inspected in patients with B-ALL. ...

Journal: :Haematologica 2008
Hareth Nahi Hans Hägglund Thomas Ahlgren Per Bernell Mats Hardling Karin Karlsson Vladimir Lj Lazarevic Mats Linderholm Bengt Smedmyr Maria Aström Helene Hallböök

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impa...

آقا محمدی, اصغر, دیوسالار, کوروس, رامیار, اصغر, صفری, زهرا, عظیمی, سیروس, محمودی, مجید,

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, characterized by excess lymphoblasts, and immature white blood cells that are continuously multiplying and overproducing in the bone marrow. The aim of this investigation was to measure the sensitivity of lymphocytes against gamma irradiation in patients with acute lymphoblastic leukemia, and also find ou...

Journal: :international journal of molecular and cellular medicine 0
atefeh seghatoleslam department of biochemistry, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) farzaneh bozorg-ghalati department of biochemistry, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) ahmad monabati department of pathology, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) mohsen nikseresht cellular and molecular research center, yasuj university of medical sciences, yasuj, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (yasouj university of medical sciences) ali akbar owji department of biochemistry, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

ubiquitin - proteasome system (ups), the major protein degradation pathway in the cells, typically degrades short - lived and damaged proteins and regulates growth and stress responses. this pathway is altered in various cancers, including acute lymphoblastic leukemia (all). all begins with a change in bone marrow cells and is the most common type of leukemia in children under 15 years. ube2q1 ...

Journal: :international journal of pediatrics 0
ali ghassemi associate professor of pediatric hematology and oncology, mashhad university of medical sciences, mashhad, iran. nosrat ghaemi associate professor of pediatric endocrine and metabolism, mashhad university of medical sciences, mashhad, iran. monireh saffar yazdi resident of pediatrics, mashhad university of medical sciences, mashhad, iran.

introduction:  acute lymphoblastic leukemia (all) is the most common malignancy in children and the main form of childhood leukemia (75%). all different treatment options have a great impact on children weight and appetite. the improving prognosis for children with cancer refocuses attention to long-term outcomes with an emphasis on quality of life. more survival rate allows researchers to eval...

Journal: :iranian journal of pediatric hematology and oncology 0
m forat-yazdi .department of internal medicine, shahid sadoughi university of medical sciences, yazd, iran. f hosseini-biouki department of psychology, shahid sadoughi university of medical sciences, yazd, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences) j salehi faculty of pharmacy, shahid sadoughi university of medical sciences, yazd, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences) h neamatzadeh .hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences) r masoumi dehshiri .hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran. 5.nutrition and foسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences)سازمان های دیگر: nutrition and food security research centre, shahid sadoughi university of medical sciences, yazd, iran. z sadri hematology and oncology research center, shahid sadoughi university of medical sciences, yazd, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (shahid sadooghi university of medical sciences)

background evidence indicates rfc1 g80a polymorphism as a risk factor for a number of cancers. increasing studies have been conducted on the association of rfc1 g80a polymorphism with acute lymphoblastic leukemia (all) risk. however, the results were  controversial. the aim of the present study was to derive a more precise estimation of the relationship.  materials and method pubmed, embase, we...

Journal: :Haematologica 2011
Amy L Sherborne Kari Hemminki Rajiv Kumar Claus R Bartram Martin Stanulla Martin Schrappe Eleni Petridou Agnes F Semsei Csaba Szalai Daniel Sinnett Maja Krajinovic Jasmine Healy Marina Lanciotti Carlo Dufour Stefania Indaco Eman A El-Ghouroury Ruchchadol Sawangpanich Suradej Hongeng Samart Pakakasama Anna Gonzalez-Neira Evelia L Ugarte Valeria P Leal Juan P M Espinoza Azza M Kamel Gamal T A Ebid Eman R Radwan Serap Yalin Erdinc Yalin Mehmet Berkoz Jill Simpson Eve Roman Tracy Lightfoot Fay J Hosking Jayaram Vijayakrishnan Mel Greaves Richard S Houlston

Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms. Such studies have served to highlight difficulties in conducting statistically and methodologically rigorous investigations into acute lymphoblas...

Background & Objective: Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry. Methods: This study evaluated 89 patients referred from all over th...

Journal: :American journal of clinical pathology 2015
Sanam Loghavi Jeffery L Kutok Jeffrey L Jorgensen

OBJECTIVES This session of the 2013 Society of Hematopathology/European Association for Haematopathology Workshop was dedicated to B-acute lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (LBL) with recurrent translocations and not otherwise specified. METHODS In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent literature on the resp...

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