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MBX-102/JNJ-39659100 (MBX-102) is a selective, partial PPAR-γ agonist that lowers glucose in the absence of some of the side effects, such as weight gain and edema, that are observed with the TZDs. Interestingly MBX-102 also displays pronounced triglyceride lowering in preclinical rodent models and in humans. Although in vitro reporter gene studies indicated that MBX-102 acid is a highly select...

Two once-a-month preparations cyclo provera (Depo-medroxy Progesterone Acetate 25 mg and Estradiol Cypionate 5 mg) and HRP-102 (Norethisterone enanthate 50 mg and Estradiol Valerate 5 mg) were tried in two groups of women by random allocation, and their effectiveness, complaints and reasons for discontinuation were studied. A total of 206 women were admitted (104 on cyclo provera and 102 on HRP...

Jennie Johnstone, MD; Mark Loeb, MD, MSc; Koon K. Teo, MBBCh, PhD; Peggy Gao, MSc; Leanne Dyal, MSc; Lisheng Liu, MD; Alvaro Avezum, MD, PhD; Ernesto Cardona-Munoz, MD; Peter Sleight, MD; Robert Fagard, MD, PhD; Salim Yusuf, MD, DPhil; on behalf of the Ongoing Telmisartan Alone and in Combination With Ramipril Global EndPoint Trial (ONTARGET) and Telmisartan Randomized Assessment Study in ACE I...