Aim of the study is to investigate the Nephroprotective activity of ethanolic extract taken from Melia azadirachta leaves, against APAP (Acetaminophen) induced nephrotoxicity. The phytochemical screening was carried out on the leaf extracts of Melia azadirachta, revealed the presence of active ingredients such as Phytol, Squalene, Oleic Acid, 2-Piperidinone, N-[4-bromo-n-butyl]. Leaves of Melia...

Argwadhadhi Kwatham is a compound preparation of 3 single drugs viz cassia fistula L. Azadirachta indica A., Tinospora cordifolia L. Literature survey show tat all3 ingredients are very effective for skin diseases. Kahayams prepared individually with these 3 drugs was found to be more effective for skin dideases. This paper deals with a comparative study of the chemical constituents present in ...

Photolysis of Salannin (1), an important bioactive compound from Azadirachta indica A.Juss (Neem), affords ∆-isosalanninolide (2), a hitherto unknown compound, along with isosalanninolide (3) and salanninolide (4). A probable mechanism has been suggested. While the mechanism of formation of 2 involves both a [4+2] cycloaddition and a [1,3] sigmatropic shift in the furan and D-rings, respectivel...

A phellophytic fungus Phomopsis (Endophytic fungi residing in the Bark) of Azadirachta indica screened for the presence of melanin on their hyphae using an alkali procedure, yielded a dark brown pigment. The purified pigment was subjected to various chemical and physical tests that are diagnostic for melanin. The pigment responds positively for all the diagnostic tests for melanin. Further stud...

Subcutaneous treatment of 50% EtOH extract of neem bark (Azadirachta indica A. juss) to male rats at the dose of 10 mg for 30 days caused arrest of spermatogenesis. The diameter of serminiferous tubule, Leydig cell nucleus and epithelial heights of epididymides were significantly reduced (p≤0.001). Sperm motility and density were significantly reduced. Reduced testicular and accessory organ pro...

Objective: The present study was conducted to determine the hypoglycemic and antioxidant potential of polyherbal formulation in alloxan induced diabetic rats. Study Design: In five different groups an aqueous suspension of herbal mixture containing equal amounts of– Azadirachta indica, Gymnema sylvestre, Momordica charantia, Syzigium cumini, Trigonella foenum was administered orally once a day ...

The piscicidal potential of water-extract mesocarp of Azadirachta indica (L) was studied in static bioassay experiment with continuous aeration to determine its acute toxicity The mortality rate and opercular ventilation under laboratory conditions over 96 hr exposure were monitored. The 96 hrLC50 was 81.28 mgl(-1) while the threshold value was 21.13 mgl(-1). The fish exhibited respiratory dist...

Mammalian ovary is a dynamic organ that is responsible for the production of competent oocytes required for successful fertilization and early embryonic development [1,2]. The meiotic competency folliocular is achieved within the follicular environment during final stages of folliculogenesis [3-7]. The achievement of meiotic competency starts in diplotene arrested oocytes, possessing germinal v...

Penelitian etnobotani intara (Azadirachta indica A. Juss.) telah dilakukan di Kabupaten Buleleng Bali. Kajian yang meliputi kajian botani, etnoekologi, etnofarmakologi, etnoantropologi, dan etnoekonomi, dengan menggunakan metode jelajah wawancara terhadap tokoh masyarakat, agama budaya, balian serta pengrajin kayu. Hasil diperoleh menunjukkan bahwa intaran lokasi penelitian umumnya berhabitus p...

The authors describe three cases of severe accidental poisoning by plants used as part of a traditional treatment in Mayotte. The established, or suspected, toxicity of Thevetia peruviana (Yellow oleander), Cinchona pubescens (Red quinine-tree), Melia azaderach (Persian lilac, also called china berry) and Azadirachta indica (Neem), is discussed. The clinical presentation is cardiac (atrioventri...