Organic azides are well-established as versatile compounds that can act as precursors of different heterocycles (triazoles, triazolines, tetrazoles, etc.) or other nitrogen-containing compounds, such as amines (Staudinger reduction, Curtius rearrangement) or imines (Schmidt rearrangement, aza-Wittig reaction). Besides the ubiquitous copper-catalysed azide–alkyne cycloaddition reaction, two appl...

In the aza-Morita–Baylis–Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK) promoted by chiral phosphine Lewis base: (R)-2'-diphenylphosphanyl[1,1']binaphthalenyl-2-ol (LB1) (10 mol %), the aza-Morita–Baylis–Hillman adducts were obtained in good yields with high ee (70–94 % ee) at –30 °C in THF. The scope and limitations of this reaction have been disclosed.

The development of a stereoselective aza-Piancatelli reaction to access 4-aminocyclopentenones is reported. This transformation relies on the use chiral o-sulfinyl anilines as inductors afford targeted products in good excellent yields. Remarkably, high value-added cyclopentenones could be obtained drs up >95:5, depending upon furan substitution pattern.

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. The catalyst is reusable without significant decreases in its activity after four t...

Southern rootworm (Diabrotica undecimpunctata howardi) affects several plants such as soybean, sorghum, wheat, cucumber, alfalfa, cucurbits and it is most damaging to corn and peanuts. The pheromone based “attract and kill” strategy is one of the powerful ways to control pest population. To address our key objective of the practical utility of the synthetic pheromone, we have developed a simple...

Leukotriene B4(LTB4), a metabolite of arachidonic acid, has been reported to have various pharmacological actions such as chemotaxis, chemokinesis, aggregation and degranulation of leukocytes in vitro.' Therefore, it is thought to be a primary mediator in inflammatory and allergic states, and inhibitors of its actions are expected to have therapeutic potential. We planned to synthesize several ...

Initially, lasubin II was synthesized diastereoselectively in racemic form [3]. Asymmetric syntheses of lasubin II were achieved based on stereoselective transformations of enantiomerically pure substrates [4] or, for example, via a diastereoselective aza-Diels-Alder reaction using a resolved chiral arylaldehyde tricarbonylchromium complex [5]. Recently, an enantioselectively catalyzed aza-Diel...