The nucleophilic cyclopropanation of hexa-1,5-diene-3,4-diones with bis(iodozincio)methane afforded the Zn alkoxides of cis-dialkenylcyclopropane-1,2-diols stereoselectively. The subsequent oxy-Cope rearrangement afforded the corresponding Zn alkoxides of 5,6-dialkylcyclohepta-3,7-diene-1,3-diols.

Travelling without moving. A Ferrier rearrangement on commercial glycals brings the double bond from position 1,2 to 2,3. Subsequent Aza-Wacker reaction allows both a 3,4-cis amination at 3 and movement of restoring glycal. These motions, reminiscent swing, enable synthesis 3-amino-3-deoxyglycals. Epoxidation/Glycosylation 3-amino-3-deoxygalactal derivative provide disaccharide with high yield,...

The development of a new platform to initiate the cascade rearrangement of furans for the formation of functionalized cyclopentenone building blocks is reported. This methodology allows the creation of congested vicinal stereogenic centers with high diastereoselectivity through a 4π-electrocyclization process.

Well-represented in natural products and biologically active molecules, the cyclopentenone scaffold has long been an inspiration for the development of new methodologies. In 1976, Piancatelli and co-workers reported a new method for the synthesis of 4-hydroxycyclopentenone derivatives by an acid-catalyzed rearrangement of suitable 2-furylcarbinols (Scheme 1). The overall transformation is belie...

Background: DNA molecule of the eukaryotic cells is found in the form of a nucleoprotein complex named chromatin. Two epigenetic modifications are critical for transcriptional control of genes, including acetylation and DNA methylation. Hypermethylation of tumor suppressor genes is catalyzed by various DNA methyltransferase enzymes (DNMTs), including DNMT1, DNMT2, and DNMT3. The most well chara...

In this paper, to cope with the stochastic dynamic (or multi-period) problem, two new quadratic assignment-based mathematical models corresponding to the dynamic and static approaches are developed. The product demands are presumed to be dependent uncertain variables with normal distribution having known expectation, variance, and covariance that change from one period to the next one, randomly...