Objectives: By MRI to assess the efficacy of addition of anakinra for controlling synovitis and stopping erosive progression in patients with clinically active RA despite receiving methotrexate, and to determine the predictive value of MRI for subsequent radiographic erosive progression. Methods: 100 mg anakinra subcutaneously/day was added to the treatment of 17 patients with clinically active...

PURPOSE To conduct an in vitro strength test for the Joshi External Stabilising System (JESS) for stabilisation of tibial fractures using a cadaveric tibia and steel rods. METHODS The configuration of the JESS specimens was based on a 62-year-old man with a metaphyseal tibial fracture. Two types of JESS specimens were prepared, using either the tibia of an average male adult cadaver (n=1) or ...

A new model characterizing the response of a multi-strand wire rope subjected to axial tension and axial torque is presented in this paper. Apart frommost of previous approaches which deal with a straight wire strand, the present model fully considers the double-helix structure in multi-strand configuration. To be further, a new method to compute local deformation parameters (two curvatures and...

It has become widely accepted that the osmolality gradient along the corticomedullary axis of the mammalian outer medulla is generated and sustained by a process of countercurrent multiplication: active NaCl absorption from thick ascending limbs is coupled with the counterflow configuration of the descending and ascending limbs of the loops of Henle to generate an axial osmolality gradient alon...

Thermal stress, wear and material damage produce effects of high-cycle fatigue failures in aircraft engines. The loading configuration on turbine blades of aircraft engines consists of an axial load. The axial load is the centrifugal force combined with the tensile and compressive loads, caused by the natural vibrations of the blades themselves. Low-cycle fatigue and high-cycle fatigue loading ...

Propagation of energy along the sound channel axis cannot be formally described in terms of geometrical acoustics due to repeated cusped caustics along the axis. In neighborhoods of these cusped caustics, a very complicated interference pattern is observed. Neighborhoods of interference grow with range and overlap at long ranges. This results in the formation of a complex interference wave--the...

In the proximal tubule of the kidney, Na(+) and HCO(3)(-) reabsorption vary proportionally with changes in axial flow rate. This feature is a critical component of glomerulotubular balance, but the basic mechanism by which the tubule epithelial cells sense axial flow remains unexplained. We propose that the microvilli, which constitute the brush border, are physically suitable to act as a mecha...

Pipe vibration is often excited in the deep ocean by ship motions, wave forces and vortex shedding. Elastic joints along the pipe are modeled in an attempt to move the resonance frequencies away from the pipe system. The numerical examples focus on the investigation of single and multiple elastic joints along a long pipe and their effect on three-dimensional (3-D) nonlinear coupled pipe respons...

Quantum effects inside the chiral bag induce a color anomaly which requires a compensating surface term to prevent breakdown of color gauge invariance. We show that the presence of this surface term first discovered several years ago allows one to derive in a gauge-invariant way a chiral-bag version of the Shore-Veneziano two-component formula for the flavor-singlet axial charge of the proton. ...

Performance evaluation of an axial flux surface mounted permanent magnet (PM) field controlled TORUS type (FCT) disc machine is presented in this paper. This new machine is an axial flux configuration with true field weakening capability since the flux is controlled by the DC field winding rather than opposing the magnets. Structure and operating principles are summarized in the first section. ...