BACKGROUND The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide beta cell regeneration. CONCLUSION High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mell...

introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...

the introduction and evolution of hematopoietic stem cell transplantation (hsct) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. today, hsct is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

The combination of genetic modification and hematopoietic stem cell (HSC) transplantation may provide the necessary means to develop an alternative treatment option to conventional antiretroviral therapy. As HSCs give rise to all hematopoietic cell types susceptible to HIV infection, modification of HSCs is an ideal strategy for the development of infection-resistant immune cell populations. Al...

OBJECTIVE The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells. MATERIALS AND METHODS...

Background: Hematopoietic stem cell transplantation (HSCT) is an effective method for the treatment of hematological malignancies, severe aplastic anemia, and myelodysplastic syndromes. The most common infectious complication after HSCT cytomegalovirus (CMV) infection. purpose this study was to analyze status research related CMV infection by conducting a literature search CMV, hematopoietic, t...

Background Autologous hematopoietic stem cell transplantation (AHSCT) is one of the standard treatment modalities for patients with multiple myeloma (MM) under 65 years age. Renal failure, significant disease comorbidity, significantly affects choices. There are conflicting data in literature regarding dose melphalan to be used AHSCT renal failure and comorbid conditions. This study aimed compa...

CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation have cosponsored these guidelines for preventing opportunistic infections (OIs) among hematopoietic stem cell transplant (HSCT) recipients. The guidelines were drafted with the assistance of a working group of experts in infectious diseases, transplantation, and public health. For the pu...

Autologous hematopoietic stem cell transplantation (auto-HSCT) is presently the only disease-modifying strategy for treatment of systemic sclerosis (SSs) that has Level A evidence, effectiveness which been proven in three controlled clinical trials: ASSIST, ASTIS, and SCOT. Despite positive results obtained with use this option, issues related to its tolerability safety remain unresolved. The c...

background nowadays, it has been found that the mental state of caregivers may have a noticeable effect on both patient and caregiver’s health. this study was conducted to determine the burnout and general health status of the hematopoietic stem cell transplantation nurses in tehran, iran. methods in a cross-sectional study, burnout and general health status of 65 hematopoietic stem cell transp...