Osteoarthritis (OA) affects several hundred million people and is one of the leading causes of disability around the world. Aging is the most influential risk factor for developing OA. Cartilage has a limited ability to spontaneously heal; therefore, it needs surgical intervention in case of cartilage defects caused by traumatic injury or degenerative disease. Due to the shortage of autologous ...

BACKGROUND A gold standard treatment for articular cartilage injuries is yet to be found, and a cost-effective and predictable large animal model is needed to bridge the gap between in vitro studies and clinical studies. Ideally, the animal model should allow for testing of clinically relevant treatments and the biological response should be reproducible and comparable to humans. This allows fo...

UNLABELLED The ability to repair damaged cartilage is a major goal of musculoskeletal tissue engineering. Allogeneic (same species, different individual) or xenogeneic (different species) sources can provide an attractive source of chondrocytes for cartilage tissue engineering, since autologous (same individual) cells are scarce. Immune rejection of non-autologous hyaline articular cartilage ha...

Cartilage injury is a leading cause of functional disability and pain. A number of techniques of cartilage repair are available, with variable outcomes expected, depending on the method used and the characteristic of the cartilage lesion. Cartilage restoration treatments should ideally provide durable repair tissue for a wide range of lesion sizes and types. Advanced cell-based therapies, such ...

introduction: laryngotracheal stenosis can be caused after traumatic injuries to the neck from the subglottic larynx to the trachea. patients with laryngotracheal stenosis often need a tracheotomy and occasionally may become tracheotomy dependent. different procedures have been described for the management of these lesions. management options include techniques of endoscopic dilation, laser res...

Fulkerson originally designed the tibial tuberosity anteromedialization technique to address patellofemoral pain associated with patellofemoral chondrosis in conjunction with patellofemoral tilt and/or chronic patellar subluxation while avoiding the complication rate of the Maquet tibial tuberosity elevation.12 The anteromedialization technique transferred areas of patellofemoral loading throug...

Cell-based cartilage repair procedures are becoming more widely available and have shown promising potential to treat a wide range of cartilage lesion types and sizes, particularly in the knee joint. More recently, techniques have evolved from 2-step techniques that use autologous chondrocyte expansion to 1-step techniques that make use of mesenchymal stem cells (MSCs) embedded onto biocompatib...

Objective: Twenty patients who presented to the ENT, head and neck department with nasal septal abscess were retrospectively studied. Design: Retrospective study. Setting: KVG Medical College and Hospital, Sullia. Study period: January 2006 to June 2010 (54 months) Patients: Twenty patients (17 males and 3 females), aged between 7 to 45 years (average age 25.25 years), with nasal septal abscess...

BACKGROUND Numerous treatment methods for osteochondral repair have been implemented, including auto- and allogeneic osteochondral transplantations, combined bone and chondrocyte transplantations, and synthetic implants, but no gold standard treatment has been established. We present preliminary data on a combined autologous bone and cartilage chips: autologous dual-tissue transplantation (ADTT...

INTRODUCTION Second-generation autologous chondrocyte implantation with scaffolds stabilizing the grafts is a clinically effective procedure for cartilage repair. In this ongoing prospective observational case report study, we evaluated the effectiveness of BioSeed-C, a cell-based cartilage graft based on autologous chondrocytes embedded in fibrin and a stable resorbable polymer scaffold, for t...