We report a case of a 15-year-old boy with autoimmune hepatitis lacking common serologic markers and normal gammaglobulinemia associated with immune thrombocytopenia and family history of psoriasis. He presented to our department with a 4-year history of a cervical posterior lymphadenopathy and recent petechiae. Previous laboratory results 6 months before already showed hepatocellular injury. A...

A 50-year-old woman was diagnosed with acute-onset autoimmune hepatitis. She did not respond to steroid therapy including pulse therapy, and was subsequently treated with living donor-liver transplantation 36 days after the beginning of steroid therapy. Except for a period of transient mild acute rejection, her liver function tests remained within a normal range for 2.5 years after the operatio...

NAGASAKI, F., UENO, Y., MANO, Y., IGARASHI, T., YAHAGI, K., NIITSUMA, H., OKAMOTO, H. and SHIMOSEGAWA, T. A Patient with Clinical Features of Acute Hepatitis E Viral Infection and Autoimmune Hepatitis. Tohoku J. Exp. Med., 2005, 206 (2), 173-179 ── Hepatitis E virus (HEV) is one of the major causative agents of acute hepatitis in many developing countries. Recent intensive examination has revea...

Background Chronic liver diseases (CLD) in children represent a growing health problem with significant morbidity and mortality. This study aimed to define the clinicopathological pattern of pediatric CLD in Sohag University Hospital, Sohag,Upper Egypt. Materials and Methods A total of 151children with CLD were included in a prospective hospital-based study from June 2014 to May 2018. Cases of...

INTRODUCTION Autoimmune polyendocrine syndrome type 2 is a rare disorder. Its prevalence in western populations has been reported as 1.5 to 4.5/100,000. On the other hand, its prevalence in Egypt is unknown. It is characterized by the association of autoimmune Addison's disease with thyroid autoimmune diseases and/or type I diabetes mellitus. Hepatitis C virus infection is an important public h...

introduction worldwide, chronic liver disease is a major cause of morbidity and mortality. causes of elevated serum alanine aminotransferase (alt) levels vary depending on the population under study. the aim of this study is to evaluate the frequency and causes of persistently elevated alt levels in patients of the gastroenterology (gi) clinics in ghaem and emam reza hospitals in mashhad, iran....

microemulsion formulation of cyclosporin a (csa) in autoimmune hepatitis (aih)

Autoimmune Liver Diseases (ALDs) include Auto Immune Hepatitis (AIH), Primary Biliary Cirrhosis (PBC), and Primary Sclerosing Cholangitis (PSC). Pernicious Anemia (PA) involves an autoimmune process in which atrophy of the gastric mucosa reduces the production of Intrinsic Factor (IF) via parietal cells, inducing vitamin B12 deficiency and megaloblastic anemia [1-5]. Although autoimmune disease...

• The diagnosis of autoimmune hepatitis is based on specific immunological, histological and biochemical characteristics after exclusion of other causes of liver disease including viral hepatitis. • Hepatitis E virus infection should be considered in the differential diagnosis of autoimmune hepatitis. • Prednisone, prednisolone, or budesonide are first line treatment options for autoimmune hepa...

 Acute hepatitis E is becoming increasingly recognised in Europe with up to 40% of the population in Southern France being exposed to the virus, which is harboured in pigs. Patients with known liver disease may present with acute hepatitis E and present a diagnostic challenge. For example patients with autoimmune hepatitis (AIH) who are immunosuppressed and contract hepatitis E may be at increa...