HIV has been linked to several autoimmune disorders since its emergence in the 1980s. By affecting different cells and pathways in the immune system, HIV induces the development of certain autoimmune diseases while prohibiting the emergence of others. Dermatomyositis has been rarely described in patients with HIV. We present a case of dermatomyositis in a patient with HIV and explore the pathog...

We report here a patient with myelodysplastic syndromes (MDS), which was complicated with several autoimmune disorders and asymptomatic immunologic abnormalities. An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss. Furthermore, clinical examinations revealed that she also had Add...

Kabuki syndrome (also called Niikawa-Kuroki syndrome) is a rare genetic disease described for the first time in Japan, characterised by anomalies in multiple organ systems and often associated with autoimmune disorders and impaired immune response. We herein report the clinical history, the therapeutic approach and the outcome of two children with Kabuki syndrome who developed autoimmune haemat...

common variable immunodeficiency (cvid) is a heterogeneous group of disorders characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura (itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders which may be seen in association with cvid. among 85 cvid patients, seve...

223 Useful animal models for the investigation of autoimmune disorders that involve the brain are essential, especially in children in whom access to the CNS is limited. The paucity of such models can hinder an understanding of causation, pathogenic mechanisms, and treatments. This is particularly true when one is investigating postulated antibody-mediated disorders in which evidence supporting...

Individuals with type 1 diabetes are at increased risk for the development of additional autoimmune disorders compared with the general population (1–11). Autoimmune thyroiditis (AIT) and celiac disease are relatively common among patients with type 1 diabetes, with prevalence rates of 17 and 6%, respectively (4). We sought to examine the relationship between age at onset of type 1 diabetes and...

Autoimmune disorders are frequent in chronic lymphocytic leukemia (CLL). Some drugs such as fludarabine may increase the risk of these phenomena and may even be fatal. The management of autoimmune disorders is not standard and corticosteroid is the most frequently used drug in these situations. Here, a case with CLL and severe autoimmune hemolytic anemia associated with fludarabine and successf...