Current American Association for the Study of Liver Diseases (AASLD) liver transplant evaluation guidelines include both adult and pediatric patients. While pediatric liver transplants account for 7.8% of all liver transplants in the United States, sufficient differences between pediatric and adult patients seeking liver transplantation (LT) now require independent, yet complementary documents....

Small GTP-binding proteins in the ADP ribosylation factor (Arf) family are master regulators of vesicle-mediated protein transport in the secretory and endocytic pathways (1). There are multiple members of this family in eukaryotic cells, with the lineage starting with Arf1 and its siblings (Arf2–Arf5) and extending to the more distant relatives Arf6, Sar1, and Arf-like (Arl) proteins. All thes...

Transmembrane lipid transporters are believed to establish and maintain the phospholipid asymmetry in biological membranes; however, little is known about the in vivo function of the specific transporters involved. Here we report that developing erythrocytes from mice lacking the putative phosphatidylserine (PS) flippase, ATP11C showed a lower rate of PS translocation in vitro compared to eryth...