Introduction Atopic dermatitis is a chronic inflammatory disorder of the skin, charachterised by a TH2 skewed cytokine profile, usually elevated total serum IgE and can be co coexpressed with other atopic clinical manifestations. The atopic skin is prone to bacterial colonization and that has an effect on immunological parameters. Atopic Dermatitis has been correlated with IgG hypoglobulinaemia...

Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries. Complex interactions between genetic and environmental factors are known to play an important role in the pathophysiology of atopic dermatitis. However, we still lack a detailed picture of the pathogenesis of this disease. Thus, it is of importance to develop appropriate a...

VIDAL (1886) first described cataract in young patients subject to attacks of pruritis followed by lichenification and associated with asthma. Andogsky (1914) described four cases of unclassified skin disease with cataract as 'dermatogenous cataract', and Kugelberg (1934) used the term 'syndermatotic juvenile cataract'. Brunsting (1936) reported ten cases of atopic dermatitis with juvenile cata...

Bronchial responsiveness (histamine PC20) and peripheral blood eosinophil counts were measured in 23 asthmatic subjects, of whom 14 were atopic and nine non-atopic. In the group as a whole there was an inverse correlation between baseline eosinophil count and histamine PC20 (r = -0.71; p less than 0.001). For atopic subjects a relationship between eosinophil count and histamine PC20 was observe...

Staphylococcal superantigens (SAG) are implicated in the inflammation of atopic dermatitis. As SAG mediated diseases may be modified by specific antibodies, the antibody response to SAG in atopic dermatitis was investigated. Immunoglobulin (Ig) G to staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin 1 (TSST-1) were measured by sandwich enzyme ...

Introduction: Peroxisome proliferatorsactivated receptors (PPARs) represent a major research target for the understanding and treatment of many skin diseases, such as benign epidermal tumors, psoriasis and atopic dermatitis. Aim: Estimate and analyze the PPAR gamma expression and its pathological role in psoriasis and atopic dermatitis. Materials and Methods: Fifteen patients with atopic dermat...

The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (> 100 kU/l) in 79.7% of adults an...

background: the pathogenesis of atopic dermatitis (ad) remains to be determined; recently a possible change in the immune system with production of immunoglobulins is proposed. as vitamin e is a potent antioxidant, with the ability to decrease the serum levels of immunoglobulin e (ige) in atopic patients, we aimed to evaluate the effect of oral vitamin e on treatment of ad.materials and methods...

Aim: Bronchial mucosal inflammation is one of the major characteristics of atopic asthma. Th2 activation and the related cytokine profile, eosinophil activation and infiltration play the main role in the pathogenesis of atopic asthma. The aim of this study was to demonstrate the activation and RANTES (regulated on activation, normal T-cell expressed and presumably secreted) expression of periph...

atopic dermatitis is one of the most common allergic diseases that almost always respond to conventional therapies with topical emollient, topical corticosteroids, systemic antihistamines and allergic abstinence. however few cases of atopic dermatitis with severe course do not respond to conventional therapies and high dose of intravenous immunoglobulin or cyclosporine are recommended for them....