نتایج جستجو برای: atherogenesis
تعداد نتایج: 4888 فیلتر نتایج به سال:
For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific proinflammatory oxidized phospholipids that result from the oxidation of LDL phospholipids containing arachidonic acid and that are recognized by the innate immune system in animals and humans. These ...
Microsomal prostaglandin E synthase-1 (mPGES-1) in myeloid and vascular cells differentially regulates the response to vascular injury, reflecting distinct effects of mPGES-1-derived PGE2 in these cell types on discrete cellular components of the vasculature. The cell selective roles of mPGES-1 in atherogenesis are unknown. Mice lacking mPGES-1 conditionally in myeloid cells (Mac-mPGES-1-KOs), ...
Atherosclerosis remains one of the major causes of death and premature disability in developed countries. Though atherosclerosis was formerly considered a bland lipid storage disease, substantial advances in basic and experimental sciences have illuminated the role of endothelium, inflammation and immune mechanisms in its pathogenesis. Current concept of atherosclerosis is that of a dynamic and...
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