Background : Till date there is no published multi-institutional data regarding the epidemiological profile of pediatric brain tumors in India. Aim : The present retrospective study analyses the histological spectrum of pediatric age group brain tumors in seven tertiary care hospitals in India. Material and Methods : Data regarding frequencies of various primary brain tumors (diagnosed accordin...

Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astro...

OBJECT The aim of this study was to evaluate the impact of CCNU chemotherapy alone on low-grade glioma (LGG) growth dynamics. METHODS The authors measured the evolution of the mean tumor diameter (MTD) in adult patients with LGG before (n=28 patients) and after (n=38 patients) CCNU administration. RESULTS Natural (spontaneous) growth of LGG in the present study was 4.3 mm/year (range 2.1-6....

Lifetime job histories from a population-based, case-control study of gliomas diagnosed among adults in the San Francisco Bay area between August 1991 and April 1994 were evaluated to assess occupational risk factors. Occupational data for 476 cases and 462 controls were analyzed, with adjustment for age, gender, education, and race. Imprecise increased risks were observed for physicians and su...

This article reviews current perspectives in the classification and grading of astrocytomas in children and calls attention to several histologically distinct groups of low-grade tumors that characteristically arise during childhood. Recognition of these tumors and the range of histological features that they may exhibit is essential for making rational assessments regarding their expected beha...

Nestin is an intermediate filament (IF) protein. These intermediate filament proteins are expressed mostly in neural stem cells [1-3]. Nestin is also expressed by many other stem cells and it is considered a primitive marker [4-7] . Upon differentiation, Nestin becomes down-regulated and is replaced by tissue-specific intermediate filament proteins [8]. During neuroand gliogenesis, Nestin is re...

Prerequisite for accurate resections of human brain tumors is the differentiation between tissue of tumor core and tumor margin. All tumor tissue needs to be removed to avoid tumor relaps and to enhance prognosis, but healthy tissue should not be resected coevally in order to maintain normal brain functions. Therefore, the amount of tumor cells and healthy cells in the margin of the tumor is cr...

Note Astrocytic tumors comprise a wide range of neoplasms that differ in their location within the central nervous system (CNS), age and gender distribution, growth potential, extent of invasiveness, morphological features, tendency for progression and clinical course; there is increasing evidence that these differences reflect the type and sequence of genetic alterations acquired during the pr...