BACKGROUND Airway eosinophilia is a predictor of steroid responsiveness in steroid-naïve asthma. However, the relationship between airway eosinophilia and the expression of FK506-binding protein 51 (FKBP51), a glucocorticoid receptor co-chaperone that plays a role in steroid insensitivity in asthma, remains unknown. OBJECTIVE To evaluate the relationship between eosinophilic inflammation and ...

Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the Human Platelet Antigen-1(HPA-1) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors...

In two groups of patients, 15 with asthma and 15 with chronic bronchitis, the bronchodilator effects of ipratropium bromide, of fenoterol plus theophylline, and of the combination of the three drugs, were compared using a double-blind, single-dose, placebo-controlled format. Ipratropium bromide caused rapid bronchodilatation which was not significantly different in asthmatic patients and patien...

In recent years, several studies have analysed the effects of neurotrophins on allergic inflammation and airway diseases. Elevated brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) levels have been found in bronchoalveolar lavage fluid (BALF) after allergen challenge in allergic asthmatic patients [1, 2]. It has also been shown that asthmatic patients...

The present study was undertaken to assess the difference between the normal predicted value and observed value of pulmonary function test (PFT) amongst the asthmatic patients and also to compare the aforesaid observed values between male and female asthmatic patients. Clinically diagnosed cases (male 62, female 75) of bronchial asthma attending medical out patient department of Nepal Medical C...

in asthmatic subjects there is a pronounced diurnal variation in bronchial responsiveness. if this phenomenon is due to variation in factors that control drug delivery, then it should be paralleled by a similar variation in competitive antagonist blockade. in order to study this possibility, we performed the methacholine challenge test and after 45 minutes, administered atropine by inhalation. ...

BACKGROUND A reduced platelet survival time has been described in asthmatic patients. There is also good evidence that platelets are involved in aspirin induced asthma. Since aspirin intolerant patients usually suffer from an active disease and often require anti-inflammatory treatment, it has been suggested that platelet survival time may be shorter in aspirin intolerant asthmatic subjects tha...

in this study, we evaluated the relationship between rhinosinusitis to the severity of asthma in asthmatic patients. this cross-sectional study was conducted on 90 patients with asthma referring to imam khomeini hospital in ardabil city. asthma control stepping method was used for staging of asthma severity. patients' clinical signs and paraclinical findings were individually evaluated and comp...

background asthma is a chronic inflammatory air-way disease with increasing prevalence rate during the recent years. there are studies about the relationship between asthma and infectious diseases, including the association between asthma and helicobacter pylori. according to the latest studies, there is an epidemiological correlation between asthma prevalence and prevalence of h. pylori. objec...

BACKGROUND Asthmatic patients taking low to moderate doses of inhaled topical corticosteroids have been shown to have lower bone density than those taking bronchodilators only. There is little information on bone density in asthmatic patients taking high dose inhaled corticosteroids. METHODS Bone mass was studied in three age matched groups of asthmatic patients. These comprised: 17 asthmatic...