Mepolizumab (Nucala) for severe eosinophilic asthma.

BackgroundAsthma is the most chronic inflammatory disorder of the airways in children and asthmatic patients can experience cardiac dysfunction, pulmonary hypertension and finally cor pulmonale later in life. We aimed to investigate Right Ventricular (RV) functions in asthmatic children by conventional and tissue Doppler echocardiography (TDE).Materials and Methods Pulmonary function tests, con...

Exercise challenge provokes bronchoconstriction in the majority of asthmatics. The reaction is particularly frequent in childhood, with an estimated prevalence of 70– 90% in asthmatic children, because of the high level of physical activity in this age group [1, 2]. Bronchoconstriction is maximal 5–10 min after the challenge and tends to a complete recovery within 30–90 min, depending on the de...

A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronch...

BACKGROUND Knowledge and practice about air pollution are essential subjects in special groups such as cardio-pulmonary patients. For children with air pollution-related diseases, knowledge and attitude of parents play a determining role in this respect. Since providing a coherent curriculum needs evidence-based information, this survey was conducted to assess the knowledge and practice of asth...

INTRODUCTION  The prevalence of asthma has grown considerably in recent decades, but some studies have shown stabilization of this trend. The masticatory process of asthmatic children may be altered due to asthma-related anatomo-functional changes. OBJECTIVE  The study objective was to determine the clinical and electromyographic characteristics of the masticatory process in asthmatic childre...

the aim of this study was to assess the frequency of rhinitis in asthmatic infants. a cross-sectional study was conducted using clinical data obtained from a standardized allergy work-up form that includes specific questions on common allergic diseases. asthmatic patients were seen at the first visit to the pediatric allergy unit, from january 2001 to january 2006, were selected for analysis. d...

the aim of the present study was to examine the effects of a course of aerobic exercise on pulmonary function and tolerance of activity in asthmatic patients. among the asthmatic patients, 36 patients (m= 16, f= 20) were chosen after clinical examinations, pulmonary function test, skin prick test (spt) for aeroallergen and a six minute walk test (6mwt) on their own free will. a patient was said...

PURPOSE Isocyanates are highly reactive chemicals used in a number of industries including paints. Therefore, house painters are known to be at risk for occupational exposure to isocyanates. Our objectives in this study were: (1) to investigate the possible effects of isocyanate exposition on the bronchoalveolar epithelial permeability in house painters by using Tc-99m DTPA radioaerosol lung sc...