نتایج جستجو برای: astatine
تعداد نتایج: 123 فیلتر نتایج به سال:
There is a plethora of books on the discovery of the chemical elements, such as Discovery of the Elements by M. E. Weeks. Most of these focus on the abundant and well-known elements. The book by Eric Scerri, in contrast, describes the history of the discovery of the periodic table s rarest members, some of which have no detectable natural abundance at all. In his previous book The Periodic Tabl...
BACKGROUND Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer for creating DNA double-strand breaks and is thus proposed for radionuclide therapy when bound to tumor-seeking agents. Unbound 211At accumulates in the thyroid gland, and the concept of basal radiation-induced biological effects in the thyroid tissue is, to a high degree, unknown an...
Background: Most carcinomas are prone to metastasize despite successful treatment of the primary tumor. One way to address this clinical challenge may be targeted therapy with α-emitting radionuclides such as astatine-211 (At). Radioimmunotherapy utilizing α-particle emitting radionuclides is considered especially suitable for the treatment of small cell clusters and single cells, although lesi...
We previously investigated the potential of targeted radiotherapy using a bismuth-213 ((213)Bi)-labeled anti-CD45 antibody to replace total body irradiation as conditioning for hematopoietic cell transplantation in a canine model. Although this approach allowed sustained marrow engraftment, limited availability, high cost, and short half-life of (213)Bi induced us to investigate an alternative ...
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