Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Database technology is the key technology to ensure assembly control data validity, completeness, consistency, security in the complex assembly system. A database model supporting complex assembly system was presented based on the requirement analysis of complex assembly system in data storage and extraction. The embedded database was used to storage the share visualization data for portable de...

Automatic assembly planning is recognized as an important tool for achieving concurrent product and process development thus reducing manufacturing costs. It plays an important role in designing and planning the assembly systems. In order to recommend a good sequence of assembly operations, the process planner needs to generate all such feasible sequences. In this paper, the representation of t...

Sequence planning generation is an important problem in assembly line design. A good assembly sequence can help to reduce the cost and time of the manufacturing process. This paper focuses on assembly sequence planning (ASP) known as a hard combinatorial optimization problem. Although the ASP problem has been tackled via even more sophisticated optimization techniques, these techniques are ofte...

Ribosome biogenesis is a tightly regulated, multi-stepped process. The assembly of ribosomal subunits is a central step of the complex biogenesis process, involving nearly 30 protein factors in vivo in bacteria. Although the assembly process has been extensively studied in vitro for over 40 years, very limited information is known for the in vivo process and specific roles of assembly factors. ...

The self-assembly process of a Pd2L4 cage consisting of flexible ditopic ligands and Pd(ii) ions was revealed by QASAP (quantitative analysis of self-assembly process), which enables one to obtain information about the intermediates transiently produced during the self-assembly as the average composition of all the intermediates. It was found that the dominant pathway to the cage is the formati...

Hepatitis C Virus (HCV) assembly process is the least understood step in the virus life cycle. The functional data revealed by forward and reverse genetics indicated that both structural and non-structural proteins are involved in the assembly process. Using confocal and electron microscopy different groups determined the subcellular localization of different viral proteins and they identified ...

The paper assumes a product design around modular architectures and discusses the suitability of the principle of delayed product differentiation in assemble-to-order environments. We demonstrate that this principle does not enable one to make optimal decisions concerning how variety should proliferate in the assembly process. Therefore, we propose to complement this principle in that we additi...

Gross-motion planning for assembly is commonly considered as a distinct, isolated step between task sequencing/scheduling and ne-motion planning. In this paper we formulate a problem of delivering parts for assembly in a manner that integrates it with both the manufacturing process and the ne motions involved in the nal assembly stages. One distinct characteristic of gross-motion planning for a...