background: green tea is one of the most popular beverages in the world. it is believed to have beneficial effects in the prevention and treatment of many diseases, one of which is nonalcoholic fatty liver disease (nafld). the present study investigated the effects of consumption of green tea in nafld patients. methods: this study was a double‑blind, placebo‑controlled, randomized clinical tria...

objective(s): silver nanoparticles (ag-nps) are one of the most widely used nanomaterials recently. despite the wide application of nanomaterials, there is limited information concerning their impact on human health and the environment. this study aimed to find the effects of ag-nps (40 nm) on blood serum, liver and kidney tissues of homing pigeons (columbia livia).materials and methods: columb...

Current evidence suggests that the effects of lithium on metabolic and signaling pathways in the brain may vary depending on the specific clinical condition or disease model. For example, lithium increases levels of cerebral N-acetyl aspartate in patients with bipolar disorder but does not appear to affect N-acetyl aspartate levels in normal human subjects. Conversely, lithium significantly dec...

In bee venom phospholipase A2, histidine-34 probably functions as a Brønsted base to deprotonate the attacking water. Aspartate-64 and tyrosine-87 form a hydrogen bonding network with histidine-34. We have prepared mutants at these positions and studied their kinetic properties. The mutant in which histidine-34 is changed to glutamine is catalytically inactive, while the mutants in which aspart...

Umami is a fundamental taste, associated with the molecules of monosodium glutamate and other amino acids nucleotides present in many fermented foods beverages, including wine. also plays role flavor enhancer prolongs aftertaste. In this research, aspartate, responsible for umami were quantified Italian still sparkling white wines aged through contact yeasts. The studied from sensory point view...

BACKGROUND D-aspartic acid is an amino acid present in neuroendocrine tissues of invertebrates and vertebrates, including rats and humans. Here we investigated the effect of this amino acid on the release of LH and testosterone in the serum of humans and rats. Furthermore, we investigated the role of D-aspartate in the synthesis of LH and testosterone in the pituitary and testes of rats, and th...

Substrates containing a P3 aspartic residue are in general cleaved poorly by thrombin. This may be partly due to an unfavourable interaction between the P3 aspartate and Glu192 in the active site of thrombin. In Protein C activation and perhaps also thrombin receptor cleavage, binding of ligands at the anion-binding exosite of thrombin seems to improve the activity of thrombin with substrates c...

YveA of Bacillus subtilis, a putative transporter of the amino acid/polyamine/organocation (APC) superfamily, is shown to mediate uptake of both L-aspartate and L-glutamate as well as having sensitivity to L-aspartate hydroxamate. This 14 TMS protein is the primary aspartate uptake system in B. subtilis and serves as the prototype for a new family within the APC superfamily.

Evidence has been presented in this investigation to show that the synthesis of aspartate kinase in Escherichia coli B is regulated by the ratio of the intracellular concentrations of the end products, methionine, threonine, and lysine. LLysine and L-threonine at a concentration of 5 mM repress the enzyme to the extent of 60 to 70% and 15 to 25%, respectively. On the other hand, methionine at a...