AGA3 also had a very short half-life in humans (8). Chemical modification of free amino groups can increase the plasma half-life of some asparaginase and glutaminase-aspa raginase enzymes in animals (12, 20). In previous studies, we have shown that treatment of AGA with succinic anhydnide produces a uniform preparation with the same catalytic activity and physical properties, but with an increa...

Campylobacter jejuni is the leading cause of infectious gastroenteritis in industrialized nations. Its ability to enter and survive within nonphagocytic cells is thought to be very important for pathogenesis. However, little is known about the C. jejuni determinants that mediate these processes. Through an extensive transposon mutagenesis screen, we have identified several loci that are require...

AGA3 also had a very short half-life in humans (8). Chemical modification of free amino groups can increase the plasma half-life of some asparaginase and glutaminase-aspa raginase enzymes in animals (12, 20). In previous studies, we have shown that treatment of AGA with succinic anhydnide produces a uniform preparation with the same catalytic activity and physical properties, but with an increa...

The blood brain barrier (BBB) refers to the complex anatomical barrier in the brain composed of endothelial cells, astroglia, pericytes, perivascular macrophages and basal lamina. Its selectivity controls the entry of substances into the Central Nervous System (CNS) [1]. BBB disruption affects neurodegeneration [2] and in some cases can be harnessed to deliver intravenous therapeutics to the CN...