نتایج جستجو برای: aryl grignard
تعداد نتایج: 15617 فیلتر نتایج به سال:
Studies have been made of the nuclear magnetic resonance spectra of several allylic Grignard reagents. The Grignard reagent prepared from y,y-dimethylallyl bromide appears best formulated as an equilibrium mixture of y,y-dimethylallylmagnesium bromide and qcx-dimethylallylmagnesium bromide, in which the former is the major component. The rate of interconversion of the allylic isomers is rapid o...
Compound 1 is a p38 MAP kinase inhibitor potentially useful for the treatment of rheumatoid arthritis and psoriasis. A novel six-step synthesis suitable for large-scale preparation was developed in support of a drug development program at Merck Research Laboratories. The key steps include a tandem Heck-lactamization, N-oxidation, and a highly chemoselective Grignard addition of 4-(N-tert-butylp...
The synthesis of 1,4-amino alcohols from THF treated with N-tosyliminobenzyliodinane (PhINTs) followed by a Grignard reagent under mild reaction conditions at room temperature is described herein. Various Grignard reagents were shown to be compatible, furnishing the corresponding 4-substituted-N-1,4-tosylamino alcohols in good to excellent yields. A partial or full detosylation of the N-tosyl-1...
The most abundant volatile occurring in mushrooms and responsible for the mushroom odour is 1-octen-3-ol. To meet the demand for a flavour compound yielding a mushroom odour a study was carried out on the possibility of obtaining 1-octen-3-ol synthetically. On the basis of literature data and experiments performed, the synthesis of this compound was carried out by two methods, i.e. by Grignard ...
A catalyst system able to perform highly enantioselective Cu-catalysed allylic alkylations with Grignard reagents is described.
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