Artificial neural networks (ANNs) were used as modeling tools for prediction of various drugs release patterns from hydrodynamically balanced systems (HBS) composed with Metholose 90SH (hydroxypropylmethylcellulose--HPMC). The objective was to provide predictive and data-mining models of analyzed problem. It was found that ANNs are capable to accurately predict release patterns of different dru...

In this study, a quantitative structure-pharmacokinetic relationship (QSPkR) model for the volume of distribution (Vd) values of 126 anti-infective drugs in humans was developed employing multiple linear regression (MLR), artificial neural network (ANN) and support vector regression (SVM) using theoretical molecular structural descriptors. A correlation-based feature selection (CFS) was employe...

RNA has been shown recently to playa prominent role in regulating gene expression in a wide variety of organisms. Natural examples of RNA-dependent gene regulation include modulation of transcription (Wassarman and Storz, 2000; Winkler et al., 2002), translation (Moller-Jensen et al., 200 I; Moller et al., 2002; Bartel, 2004), and the temporal stability of mRNA (Masse et al., 2003; Meister and ...

Clinical trials of single drugs intended to slow the progression Alzheimer’s Disease (AD) have been notoriously unsuccessful. Combinations repurposed could provide effective treatments for AD. The challenge is identify potentially combinations. To meet this challenge, machine learning (ML) was used extract knowledge from two leading AD databases, and then “the machine” predicted which combinati...

Today, humans live in the era of rapid growth electronic devices that are based on artificial intelligence, including significant manufacture machines perform intelligent human tasks to solve complex situations. Artificial intelligence will significantly influence development many domains, especially medical domain, which relies heavily techniques diagnosing disease data and manufacturing drugs...

background: poisoning is considered an important public health issue. considering the high prevalence of poisonings and the diversity of their ensuing symptoms, this study aimed to investigate the epidemiology of the clinical symptoms of poisoning in children admitted to shahid madani and ta'min ejtema'i hospitals of khorramabad in 2011. methods: in this cross-sectional study, the dat...

background: poisoning is a serious health problem in the world. in the intentional type, the person may attempt suicide by self-poisoning or may be poisoned by others in a criminal act. the present study was designed to investigate the causes and the frequency of poisoning cases referring to loqman hospital, tehran, iran, during summer 2010. methods: in this descriptive-analytical study, age, g...

conclusions findings reveal a significant degree of prescription errors, emphasizing the need for stringent surveillance. results a total of 227 case notes were reviewed, 129 (56.8%) of which belonged to male patients. no medication was prescribed for 13 patients, whereas 697 drug prescriptions (excluding intravenous fluids) were given for 214 patients, equaling 3.25 drugs/patient; antibiotics ...