BACKGROUND Deep infection is a debilitating complication after shoulder arthroplasty. Intra-articular injection of antibiotic can give a higher concentration compared with intravenous administration. We hypothesized that a group of patients given an intra-articular, intraoperative injection of gentamicin would report a lower infection rate than a group without local antibiotics. METHODS Betwe...

weeks. All patients were given intra-articular injections of saline or 1% procaine solution, or both, for control observations, before receiving phenylbutazone. Of the 11 patients with osteoarthritis who received 34 intra-articular injections, one derived major improvement, seven derived slight to moderate improvement, and three failed to benefit. Of 18 patients with rheumatoid arthritis, given...

Intra-articular hip injections have proven clinical value for both diagnostic and therapeutic purposes. Historically, these injections have been performed by radiologists using fluoroscopic guidance. This necessitates a radiology referral, delays the injection, and represents lost productivity for the orthopedist. Ultrasound-guided intra-articular hip injections have been described in the radio...

We undertook a prospective, randomised study in order to evaluate the efficacy of clamping the drains after intra-articular injection of saline with 1:500 000 adrenaline compared with post-operative blood salvage in reducing blood loss in 212 total knee arthroplasties. The mean post-operative drained blood volume after drain clamping was 352.1 ml compared to 662.3 ml after blood salvage (p < 0....

OBJECTIVES This study was undertaken to assess the safety and potential efficacy of intra-articular non-animal stabilised hyaluronic acid (NASHA) in patients with hip OA. METHODS This was a prospective, open-label, 3-month pilot study of a single intra-articular injection of NASHA in 31 patients. Safety outcomes were measured at 2 weeks and 3 months after treatment, as were efficacy measureme...

INTRODUCTION The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have been proven to play an important role in the pathogenesis of diseases. We focused on microRNA (miR)-210, which plays a wid...

BACKGROUND To estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection. METHODS A systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case reports were included, as were prospective and retrospective studies that reported adverse events of corticoste...

Knee osteoarthritis (OA) is a popular disease characterized by the degradation of cartilage, pain, and inflammation, which may lead to increased disability [1]. Intra-articular injection of hyaluronic acid (HA) has become a common treatment for knee OA [2]. HA is part of the substance of the synovial fluid and cartilage, and is associated with the viscoelastic properties of synovial fluid. Alth...