نتایج جستجو برای: articular chondrocyte

تعداد نتایج: 32509  

2016
Hiroshi Kobayashi Song Ho Chang Daisuke Mori Shozo Itoh Makoto Hirata Yoko Hosaka Yuki Taniguchi Keita Okada Yoshifumi Mori Fumiko Yano Ung-il Chung Haruhiko Akiyama Hiroshi Kawaguchi Sakae Tanaka Taku Saito

In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell survival and catabolic enzyme production. Here, we analyse in vivo functions of Rela in embryonic limbs and adult articular cartilage, and find that Rela protects chondrocytes from apoptosis through induction of anti-apoptotic genes including Pik3r1. During skel...

2018
Yunsup Lee Jaehoon Choi Nathaniel S. Hwang

Background Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and...

2014

When Policy Topic is covered Autologous chondrocyte implantation may be considered medically necessary for the treatment of disabling full-thickness articular cartilage defects of the knee caused by acute or repetitive trauma, in patients who have had an inadequate response to a prior surgical procedure, when all of the following criteria are met:  Adolescent patients should be skeletally matu...

Journal: :Osteoarthritis and cartilage 2002
H M van Beuningen R Stoop P Buma N Takahashi P M van der Kraan W B van den Berg

OBJECTIVE To obtain well characterized immortalized murine chondrocyte cell lines. The cell lines were obtained from mature articular chondrocytes, instead of embryonal cells which are used in most other studies. METHODS Pieces of articular cartilage were cut from murine patellae and femoral heads. Chondrocytes were isolated by digestion with collagenase. These cells were cultured in monolaye...

2006
Healey

INTRODUCTION: Human articular cartilage degeneration has been strongly associated with aging, the degree of osteoarthritis, as well as levels of biomechanical stress. Morphometric changes in the subchondral plate, chondrocyte density and levels of calcification have been implicated as causes of osteoarthritis, but these relationships remain controversial because of conflicting conclusions. For ...

2016
Zhen Cao Ce Dou Jianmei Li Xiangyu Tang Junyu Xiang Chunrong Zhao Lingyu Zhu Yun Bai Qiang Xiang Shiwu Dong

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and ant...

شیخ حسن, محسن, طباطبائی قمی, رضا, قیاثی, مهدیه, کلهر, ناصر,

Background: Although the presence of articular cartilage progenitor cells is already known, but due to lack of blood supply, its ability to heal is poor. In past, tissue engineering approaches has been mainly focused on the collection and culture of chondrocyte cells on biodegradable scaffolds such as polyglycolic acid in vitro and their autologous transplantation. Recently, due to the difficul...

Journal: :Osteoarthritis and cartilage 2004
Monica De Mattei Agnese Pellati Michela Pasello Alessia Ongaro Stefania Setti Leo Massari Donato Gemmati Angelo Caruso

OBJECTIVE To investigate the single and combined effects of electromagnetic field (EMF) exposure and the insulin growth factor-I (IGF-I) on proteoglycan (PG) synthesis of bovine articular cartilage explants and chondrocytes cultured in monolayers. DESIGN Bovine articular cartilage explants and chondrocyte monolayers were exposed to EMF (75Hz; 1.5mT) for 24h in the absence and in the presence ...

Journal: :The Journal of experimental biology 2012
Kimberly A Congdon Ashley S Hammond Matthew J Ravosa

Variation in mechanical loading is known to influence chondrogenesis during joint formation. However, the interaction among chondrocyte behavior and variation in activity patterns is incompletely understood, hindering our knowledge of limb ontogeny and function. Here, the role of endurance exercise in the development of articular and physeal cartilage in the humeral head was examined in 14 mini...

Journal: :Annals of the rheumatic diseases 1995
P J Verschure J van Marle L A Joosten W B van den Berg

OBJECTIVE To examine the distribution of insulin like growth factor-1 (IGF-1) receptors and the biological response to IGF-1 stimulation in articular cartilage of normal mouse knee joints and arthritic joints taken at various stages of experimentally induced arthritis. METHODS In situ IGF-1 receptor expression and responsiveness to IGF-1 stimulation were examined in murine articular cartilage...

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