BACKGROUND Arterial thrombosis involves platelet aggregation and clot formation, yet little is known about the contribution of genetic variation in fibrin-based hemostatic factors to arterial clotting risk. We hypothesized that common variation in 24 coagulation-fibrinolysis genes would contribute to risk of incident myocardial infarction (MI) or ischemic stroke (IS). METHODS We conducted a p...

DESCRIPTION This atlas presents the full range of arterial variations that occur in the human body. This interdisciplinary work shows variations of the arteries with schematic diagrams alongside their corresponding radiological images. Chapters begin with schematic and radiological depictions of normal arterial blood supply, followed by images of the arterial variation, to enable rapid identifi...

The anatomy of the arterial system supplying blood to the brain can influence the development of arterial disease such as aneurysms, dolichoectasia and atherosclerosis. As the arteries supplying blood to the brain develop during embryogenesis, variation in their anatomy may occur and this variation may influence the development of arterial disease. Angiogenesis, which occurs mainly by sprouting...

OBJECTIVE We studied the variable effects of norepinephrine infusion on cardiac output in postoperative cardiac surgical patients in whom norepinephrine increased mean arterial pressure. We hypothesized that the directional change in cardiac output would be determined by baseline cardiac function, as quantified by stroke volume variation, and the subsequent changes in mean systemic filling pres...

Fin whales have an incompliant aorta, which, we hypothesize, represents an adaptation to large, depth-induced variations in arterial transmural pressures. We hypothesize these variations arise from a limited ability of tissues to respond to rapid changes in ambient ocean pressures during a dive. We tested this hypothesis by measuring arterial mechanics experimentally and modelling arterial tran...

background: the celiac axis, superior mesenteric artery (sma), and hepatic artery are the most important branches of abdominal aorta due to their vascularization field. the aim of our study was to evaluate the prevalence of different anatomical variation of celiac axis, sma, hepatic artery, and its branches with multidetector computed tomography (mdct) angiography of upper abdomen arteries. mat...

background : identifying the sources of variation in qtc measurements is important for preventing arrhythmias during and after hemodialysis. the present study was designed to determine the correlation between the type of hemodialysis buffer and the changes in qtc interval in patients on chronic hemodialysis.   methods: fifty-nine patients on chronic hemodialysis who referred in winter 2007 to h...

effects of acute hypercapnia on the cardiovascular system (cys) were studied in the anesthetized cat. after surgery the animal was exposed to a gas mixture of 12% co2 and 25% o2 in nitrogen, and hypercapnia with low levels of arterial ph (pha) was produced for 20 minutes. in the second run the same level of hypercapnia was induced by ventilating the same cat from the above gas mixture but pha w...

The persistent trigeminal artery (PTA) is a persistent, primitive, embryonic anastomosis that provides the blood flow between vertebro-basilar system and carotid system. presence of PTA may create an advantage by providing collateral circulation during stroke as in cases leptomeningeal collaterals, external-internal anastomoses, polygon Willis. However, patients with this variation are more sus...

Arterial thrombosis is a central pathologic mechanism contributing to myocardial infarction and stroke, together the leading causes of death in developed countries. This article reviews the current state of knowledge concerning the role of inherited variation in hemostatic and inflammatory factor genes in determining the risk of arterial thrombosis/ischemic heart disease. Despite considerable p...