In this paper, the application of the double radical nucleophilic aromatic substitution (SRN1) in various dihalogenated, mostly diiodinated, π-conjugated systems as a tool for qualitatively estimating their π-conjugation is described. This approach uses electron delocalisation as a measure of π-conjugation. Electron injection into the π-system is achieved via reaction of an intermediate aryl ra...

In this paper, the application of the double radical nucleophilic aromatic substitution (SRN1) in various dihalogenated, mostly diiodinated, p-conjugated systems as a tool for qualitatively estimating their pconjugation is described. This approach uses electron delocalisation as a measure of p-conjugation. Electron injection into the p-system is achieved via reaction of an intermediate aryl rad...

What does the term "nucleophilic substitution" imply? • A nucleophile is an the electron rich species that will react with an electron poor species • A substitution implies that one group replaces another. Nucleophilic substitution reactions occur when an electron rich species, the nucleophile, reacts at an electrophilic saturated C atom attached to an electronegative group (important), the lea...

The correlation between the 1%-NMR chemical shift of the aromatic ring carbon bearing the leaving group and the yield of nucleophilic aromatic displacement with no-carrier-added [ 18Flfluoride ion was evaluated. In comparison of structurally analogous compounds (fluoro, nitro and trimethylammonium substituted benzaldehydes, benzophenones and benzonitriles), the 13C-NMR chemical shift of the rea...

Isocyanides are important building blocks in organic synthesis; however, their synthesis is time and resource consuming often unpleasant due to smelly nature. Diversification of isocyanides can be accomplished by de novo or from already existing isocyanides. In this work, we report for the first-time isocyanide diversification based on nucleophilic aromatic substitution suitable precursor The m...