There is controversy as to whether gene expression is silenced in the functional centromere. The complete genomic sequences of the centromeric regions in higher eukaryotes have not been fully elucidated, because the presence of highly repetitive sequences complicates many aspects of genomic sequencing. We performed resequencing, assembly, and sequence finishing of two P1-derived artificial chro...

We examined the effects of changing target distance from within arm's length (AL) to beyond arm's length on the onsets of electromyographic (EMG) activity of non-focal muscles for a reaching task performed while standing. Two questions were addressed. First, do changes in target distance result in consistent changes in the onsets of non-focal anticipatory muscle activity of the trunk and legs i...

Introduction: This study aims to determine the amount of hand-arm vibration transmitted from heavy electric destruction tools and the effect of using chisel with different lengths and shapes when demolishing concrete surfaces. Material and Methods: To evaluate the magnitude of hand-arm vibration on the left and right handles of two powerful electric demolition hammers commonly applied in Irani...

Abstract Background Cabotegravir + Rilpivirine Long Acting (CAB+RPV LA) every 2 months is a recommended regimen in European and US treatment guidelines for PLWH with virological suppression no known resistance to CAB or RPV. CARISEL, an implementation study, the first study where all participants switched from standard oral therapy monthly CAB+RPV. Key clinical secondary endpoints are reported....

MicroRNAs are derived from endogenous stem-loop precursors, and play important roles in various biological processes. From next-generation sequencing data, it is suggested that both the 5p-arm and 3p-arm of mature miRNAs could be generated from a single miRNA hairpin precursor; however, the current miRNA databases fail to provide comprehensive arm annotation features, which could result in ambi...