Many pharmacologically active molecules are formulated as solid dosage form drug products. Following oral administration, the diffusion of an active molecule from the gastrointestinal tract into systemic distribution requires the disintegration of the dosage form followed by the dissolution of the molecule in the stomach lumen. Its dissolution properties may have a direct impact on its bioavail...

Dissolution profiles were developed in three different pH media for the evaluation of valsartan/amlodipine (VS/AM) release from tablets. The selection of the most appropriate dissolution method was based on the calculated similarity (f2) and dissimilarity (f1) values. A new HPLC method was developed to quantify VS/AM in tablets. The method was validated in accordance with international guidelin...

BACKGROUND Scintigraphic studies have been performed to assess the release, both in vitro and in vivo, of radiotracers from tablet formulations. Four different tracers with differing physicochemical characteristics have been evaluated to assess their suitability as models for drug delivery. METHODS In-vitro disintegration and dissolution studies have been performed at pH 1, 4 and 7. In-vivo s...

This study describes various complications related to sample preparation (filtration) during development of a dissolution method intended to discriminate among different fenofibrate immediate-release formulations. Several dissolution apparatus and sample preparation techniques were tested. The flow-through cell apparatus (USP 4) was found unfit for dissolution testing of fenofibrate MeltDose fo...

Resveratrol is a nonflavonoid polyphenolic compound which has a broad range of desirable biological actions which include antioxidant, anti-inflammatory, antidiabetic, cardioprotective, and antitumor activities. However, there is concern that the bioavailability of resveratrol may limit some of its clinical utility. So, the aim of this study was to enhance the dissolution rate and oral hypoglyc...

The aim of present investigation was to improve the solubility and dissolution rate limited absorption of lornoxicam (LXM) by making solid complexes using single and double hydrophilization approaches. For this, effect of Polyvinylpyrrolidone K-30 (PVP K-30) and Poloxamer-407 (PXM407) auxiliary substances on complexation of drug with β-cyclodextrin was studied by investigating their interaction...

The objective of this work is to use Direct Monte Carlo techniques in simulating drug delivery from compacts of complex composition, taking into consideration the special features of the dissolution in vitro environment. The paper focuses on simulating a binary system, consisting of poorly-soluble drug, dispersed in a matrix of highly-soluble acid excipient. At dissolution, the acid excipient d...

Solid dispersions of tanshinone IIA (TanIIA) using hydroxyapatite (HAp) as the dispersing carrier (TanIIA-HAp SDs) were prepared by the solvent evaporation method. The formed solid dispersions were characterized by scanning electron microscopy (SEM), differential scanning calorimetry analysis (DSC), X-ray powder diffraction (XRPD) and Fourier transforms infrared (FTIR) spectroscopy. The in vitr...

The purpose of the present research was to study the effects of Ceolus KG-802 on the dissolution behavior of fenofibrate liquisolid tablets. The fenofibrate liquisolid tablets were formulated using the mathematical model described by Spireas et al. In the present research, Ceolus KG-802, a different form of microcrystalline cellulose (PH 102 grade), was used as a carrier material. The developed...