Certain forms of glaucoma are associated with displacement of the iris from its normal contour. We present here a mathematical model of the coupled aqueous humor-iris system that accountsfor the contribution of aqueous humor flow and passive iris deformability to the iris contour. The aqueous humor is modeled as a Newtonian fluid, and the iris is modeled as a linear elastic solid. The resulting...

PURPOSE To evaluate the effect of 8-bromo cGMP (Br cGMP) on aqueous humor flow rate and outflow facility in monkey eyes. METHODS. Aqueous humor flow rate was measured fluorophotometrically after topical, intracameral, or intravitreal administration of Br cGMP in one eye and normal saline in the other eye. Outflow facility was determined by two-level constant pressure perfusion after intracamera...

The acute effects of topical pilocarpine 4 per cent, administered to one eye, have been studied in replicate experiments in young volunteers. One hour after medication administration the intraocular pressure was significantly lower. The magnitude of the reduction exceeded that predicated from the significant increase of true facility of outflow. This is explained by the observation of a signifi...

No oxygen was detected on the corneal surface of human subjects breathing air or almost pure oxygen. These results suggest that the epithelium obtains all its oxygen fro the air or the palpebral conjunctiva and that the endothelium is supplied with oxygen solely by the aqueous humor.

PURPOSE To determine whether there is a circadian change of the concentration of C-type natriuretic peptide (CNP) in rabbit aqueous humor. METHODS Forty-one male white New Zealand rabbits were submitted to a 12 h light and 12 dark lighting schedule; lights on was at 0 h, lights off at 12 h. C-type natriuretic peptide was assayed at 3 light (2 h, 6 h and 10 h) and 3 dark (14,18 and 22 h) times...

Rabbits receiving subcutaneous ascorbate after corneal wounding showed significant elevation of aqueous humor ascorbate levels but no enhancement of wound breaking strength when compared to controls. In a second group of rabbits, perilimbal alkali burning reduced aqueous humor ascorbate levels one-half to one-third normal. In these perilimbally burned eyes with wounds in clear cornea, subcutane...

Purpose. This study was performed to measure the concentration of trans-resveratrol and its three metabolites in human eyes. Methods. The patients who underwent pars plana vitrectomy for rhegmatogenous retinal detachment were included. The participants were orally given trans-resveratrol-based supplement (Longevinex®). A suitable amount of conjunctiva, aqueous humor, and vitreous humor were obt...

PURPOSE High levels of ascorbic acid are known to be present in the aqueous humor of many diurnal species, whereas nocturnal animals have low concentrations of the compound. The purpose of this study was to test the hypothesis that the high concentration of aqueous ascorbate in diurnal animals protects the lens against ultraviolet (UV)-induced damage to the eye. This study compares the effect o...

A study was made in albino rabbits of the effect on aqueous humor dynamics of 100% oxygen, administered by face mask. A mean decrease in intraocular pressure of 4.9 mm Hg was found. This was accompanied by a decrease in episcleral venous pressure of 4.5 mm Hg. Anterior chamber aqueous humor flow decreased transiently after oxygen administration but returned to pre-oxygen levels after about 60 m...

The prevalence of hepatitis B virus (HBV) is particularly high in Asian countries, including Taiwan. Previous studies have reported detection of HBV surface antigens in tears and aqueous humor of HBV-seropositive individuals, suggesting that ophthalmologists may be at risk of contracting HBV infection by treatment of such patients. Herein we report the case of an asymptomatic Taiwanese HBV pati...