Three siblings (1 boy, 2 girls) with hypertension and hypokalemia are
presented, two with low plasma aldosterone and suppressed renin activity and the
eldest with a high renin and aldosterone level due to secondary changes in her
kidneys. Urinary tetrahydrocortisol (THF) was increased relative to
tetrahydrocortisone (THE). Cortisol ring A reduction constant was also lower than
normal. Thes...
