Abstract The ovary contains numerous macrophages, and macrophage depletion in mice leads to dysfunctional ovulation. Macrophage function the is presumed be related efferocytosis, however, absence of macrophages also disrupts follicular development corpus luteum development. Granulosa cells (GC) are critical ovarian follicle survival, we hypothesized that macrophage-GC crosstalk promoted GC func...

Background/Aim. The main cause for development of endometrial hyperplasia is unopposed effect estrogen on cells. aim our study was to investigate and compare cytotoxic apoptotic effects mifepristone human stromal cell line the first time. Both percentage cells were determined after 24 h treatment with different doses mifepristone. Methods. evaluated by viability assay while using flow cytometry...

Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown be pro-apoptotic some studies, but anti-apoptotic others. To investigate this phenomenon, we combine computational modeling with experimental approaches examine how the function of apoptosis varies respect expression levels its and targets. In so do...

artemisinin and its derivatives are very important new class of antimalarial drugs. one of the most important artemisinin derivatives is artemether. the antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. the aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. i...

Apoptosis, the programmed and intentional death of senescent, damaged, or otherwise superfluous cells, is natural end-point for most cells within multicellular organisms. Apoptotic are not inherently damaging, but if left unattended, they can lyse through secondary necrosis. The resulting release intracellular contents drives inflammation in surrounding tissue lead to autoimmunity. These negati...

Therapeutic potential of harmaline, a novel alkaloid, against cervical cancer cells in vitro: Apoptotic induction and DNA interaction studyParomita Bhattacharjee, Sarita Sarkar, Tapas Ghosh, Kakali Bhadra

Fractalkine (FKN) is a chemokine with several roles, including chemotaxis; adhesion; and immune damage, which also participates in cell inflammation apoptosis responds to the pathogenesis of autoimmune diseases. Given involvement regulatory T cells (Treg) diseases, this study investigated mechanism FKN renal injury Treg via p38 mitogen-activated protein kinase (p38MAPK) signaling pathway lupus-...

Abstract Schiff base compounds and their metal complexes have become important synthetic organic drugs due to extensive biological activities, which include anticancer, antibacterial antiviral effects. In this study, we investigated the cytotoxic apoptotic effects of VALD-3, a ligand synthesized from o-vanillin derivatives, on human breast cancer cells possible underlying mechanisms. 3-(4,5-Dim...

A defining cellular event in the transition from compensated hypertrophy to dilated cardiomyopathy is cardiomyocyte drop-out due to apoptosis, programmed necrosis, and autophagy. The importance of apoptosis in heart failure has been recognized for over a decade, while other forms of programmed cell death have more recently been appreciated, and their pathophysiological roles continue to be defi...